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Abstract：
Silicosis is a lung disease of fibrotic nature resulting from the inhalation and deposition of dust containing crystalline silica. Subjects exposed to the same environmental factors may show distinct radiological manifestations, and since silicosis is known as a multifactorial disease, it is plausible that individual genetic susceptibility may play a role in the pathology. This review of the literature aims to provide an assessment of the present data on the genetic association studies in silicosis and describe the genes that potentially might influence silicosis susceptibility in silica-exposed individuals.
We accessed the database of PubMed for articles published in English about interindividual genetic susceptibility to silicosis using terms related to the subject matter.
Following the evaluation process, 28 studies were included in this systematic review, including 23 original studies and 5 meta-analyses.
Regardless of the advances in the knowledge of the importance of gene variations in silicosis, more studies need to be performed, in particular, special polygenic and genome-wide investigations.
We accessed the database of PubMed for articles published in English about interindividual genetic susceptibility to silicosis using terms related to the subject matter.
Following the evaluation process, 28 studies were included in this systematic review, including 23 original studies and 5 meta-analyses.
Regardless of the advances in the knowledge of the importance of gene variations in silicosis, more studies need to be performed, in particular, special polygenic and genome-wide investigations.
摘要：
矽肺是一种纤维化性质的肺病，由吸入和沉积含有结晶二氧化硅的粉尘引起。暴露于相同环境因素的受试者可能表现出不同的放射学表现。由于矽肺是一种多因素疾病，似乎个体遗传易感性可能在病理中起作用。这篇文献综述旨在评估有关矽肺遗传关联研究的现有数据，并描述可能影响暴露于二氧化硅个体的矽肺易感性的基因。
我们使用与主题相关的术语，访问了PubMed数据库，以英文发表的有关矽肺个体间遗传易感性的文章。
在评估过程之后，本系统综述包括28项研究，包括23项原始研究和5项荟萃分析。
不管对矽肺基因变异重要性的认识有多大的进展，需要进行更多的研究，特别是,特殊的多基因和全基因组调查。
我们使用与主题相关的术语，访问了PubMed数据库，以英文发表的有关矽肺个体间遗传易感性的文章。
在评估过程之后，本系统综述包括28项研究，包括23项原始研究和5项荟萃分析。
不管对矽肺基因变异重要性的认识有多大的进展，需要进行更多的研究，特别是,特殊的多基因和全基因组调查。
