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Abstract：
BACKGROUND: Previous studies have shown inconsistent results about the usefulness of bilateral inferior petrosal sinus sampling (BIPSS) in differential diagnosis of adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome. This meta-analysis evaluated the diagnostic value of BIPSS via the published literature.
METHODS: This study searched PubMed, Embase, Web of Science, Cochrane library, and Wanfang database for published data on the use of BIPSS in Cushing syndrome differential diagnosis as of October 2019. Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and receiver operating characteristic (ROC) curves were calculated based on the relevant data.
RESULTS: This meta-analysis included a total of 23 studies with 1642 patients. The calculated sensitivity, specificity, PLR, and NLR were 0.94 (95% confidence interval, CI: 0.91-0.96), 0.89 (95% CI: 0.79-0.95), 8.8 (95% CI: 4.3-17.9), and 0.07 (95% CI: 0.04-0.11), respectively. The pooled DOR and area under the ROC curve were 129 (95% CI: 48-345) and 0.97 (95% CI: 0.95-0.98), respectively.
CONCLUSIONS: This meta-analysis indicated that BIPSS had high diagnostic value for detecting ACTH in patients with ACTH-dependent Cushing syndrome, and BIPSS should be used as an effective method to identify ACTH-secretion sources.
METHODS: This study searched PubMed, Embase, Web of Science, Cochrane library, and Wanfang database for published data on the use of BIPSS in Cushing syndrome differential diagnosis as of October 2019. Sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and receiver operating characteristic (ROC) curves were calculated based on the relevant data.
RESULTS: This meta-analysis included a total of 23 studies with 1642 patients. The calculated sensitivity, specificity, PLR, and NLR were 0.94 (95% confidence interval, CI: 0.91-0.96), 0.89 (95% CI: 0.79-0.95), 8.8 (95% CI: 4.3-17.9), and 0.07 (95% CI: 0.04-0.11), respectively. The pooled DOR and area under the ROC curve were 129 (95% CI: 48-345) and 0.97 (95% CI: 0.95-0.98), respectively.
CONCLUSIONS: This meta-analysis indicated that BIPSS had high diagnostic value for detecting ACTH in patients with ACTH-dependent Cushing syndrome, and BIPSS should be used as an effective method to identify ACTH-secretion sources.
摘要：
背景：先前的研究表明，双侧岩下窦取样（BIPSS）在促肾上腺皮质激素（ACTH）依赖性库欣综合征的鉴别诊断中的作用不一致。这项荟萃分析通过已发表的文献评估了BIPSS的诊断价值。
方法：本研究搜索了PubMed，Embase,WebofScience,科克伦图书馆,和万方数据库提供截至2019年10月在库欣综合征鉴别诊断中使用BIPSS的已发表数据。灵敏度,特异性，正似然比(PLR)，负似然比(NLR)，诊断优势比(DOR)，并根据相关数据计算受试者工作特征(ROC)曲线。
结果：本荟萃分析共纳入23项研究，共1642例患者。计算的灵敏度，特异性，PLR,NLR为0.94(95%置信区间，CI：0.91-0.96），0.89（95%CI：0.79-0.95），8.8（95%CI：4.3-17.9），和0.07（95%CI：0.04-0.11），分别。合并的DOR和ROC曲线下面积分别为129（95％CI：48-345）和0.97（95％CI：0.95-0.98），分别。
结论：这项荟萃分析表明，BIPSS对ACTH依赖性库欣综合征患者的ACTH检测具有较高的诊断价值。和BIPSS应作为鉴定ACTH分泌来源的有效方法。
方法：本研究搜索了PubMed，Embase,WebofScience,科克伦图书馆,和万方数据库提供截至2019年10月在库欣综合征鉴别诊断中使用BIPSS的已发表数据。灵敏度,特异性，正似然比(PLR)，负似然比(NLR)，诊断优势比(DOR)，并根据相关数据计算受试者工作特征(ROC)曲线。
结果：本荟萃分析共纳入23项研究，共1642例患者。计算的灵敏度，特异性，PLR,NLR为0.94(95%置信区间，CI：0.91-0.96），0.89（95%CI：0.79-0.95），8.8（95%CI：4.3-17.9），和0.07（95%CI：0.04-0.11），分别。合并的DOR和ROC曲线下面积分别为129（95％CI：48-345）和0.97（95％CI：0.95-0.98），分别。
结论：这项荟萃分析表明，BIPSS对ACTH依赖性库欣综合征患者的ACTH检测具有较高的诊断价值。和BIPSS应作为鉴定ACTH分泌来源的有效方法。
