吡唑并嘧啶氨基磺酸盐作为 ATG7 抑制剂的发现和优化。
关键词: ATG7 ATG7 inhibitor Autophagy E1 enzyme
Mesh : Autophagy / drug effects Autophagy-Related Protein 7 / antagonists & inhibitors metabolism Dose-Response Relationship, Drug Drug Discovery HEK293 Cells Humans Molecular Structure Pyrazoles / chemical synthesis chemistry pharmacology Pyrimidines / chemical synthesis chemistry pharmacology Structure-Activity Relationship Sulfonic Acids / chemical synthesis chemistry pharmacology
来 源:
DOI:10.1016/j.bmc.2020.115681
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