蛋白激酶 C 抑制剂锚定的 BRD4 PROTAC 聚乙二醇化纳米脂质体用于治疗威罗非尼耐药黑色素瘤。
关键词: ARV PEGylated nanoliposomes Palmitoyl-dl-Carnitine chloride Protein kinase C inhibitor Vemurafenib-resistant melanoma
Mesh : Humans Antineoplastic Agents / pharmacology Cell Cycle Proteins / genetics metabolism Cell Line, Tumor Drug Resistance, Neoplasm / drug effects genetics Gene Expression Regulation, Neoplastic Human Umbilical Vein Endothelial Cells Liposomes / chemical synthesis metabolism Melanocytes / drug effects metabolism pathology Models, Biological Mutation Nanocapsules / chemistry Neovascularization, Pathologic / genetics metabolism prevention & control Palmitoylcarnitine / metabolism pharmacology Polyethylene Glycols / chemistry Protein Kinase C / antagonists & inhibitors genetics metabolism Proto-Oncogene Proteins B-raf / genetics metabolism Signal Transduction Static Electricity Transcription Factors / genetics metabolism Vemurafenib / pharmacology
来 源: DOI:10.1016/j.yexcr.2020.112275