关键词: behavior genetics gene × environment interaction genome-wide association study heritability polygenic scores twin studies

Mesh : Gene-Environment Interaction Genetic Predisposition to Disease Genetics, Behavioral Genome-Wide Association Study Humans Multifactorial Inheritance Twin Studies as Topic

来  源:   DOI:10.1146/annurev-psych-052220-103822   PDF(Sci-hub)

Abstract:
Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit the first law of behavioral genetics stating that everything is heritable, and I describe results from large-scale meta-analyses of twin data and new methods for estimating heritability using measured DNA. Second, I describe new methods in statistical genetics, including genome-wide association studies and polygenic score analyses. Third, I describe the next generation of work on gene × environment interaction, with a particular focus on how genetic influences vary across sociopolitical contexts and exogenous environments. Genomic technology has ushered in a golden age of new tools to address enduring questions about how genes and environments combine to create unique human lives.
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