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Abstract：
The Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology-1 (EVH-1) domain (SPRED) family of proteins was discovered in 2001. These Sprouty-related tyrosine kinase-binding proteins negatively regulate a variety of growth factor-induced Ras/ERK signaling pathways. In recent years, SPRED proteins have been found to regulate vital activities such as cell development, movement, and proliferation, and to participate in pathophysiological processes such as tumor metastasis, hematopoietic regulation, and allergic reactions. The findings of these studies have important implications regarding the involvement of SPRED proteins in disease. Early studies of SPRED proteins focused mainly on various tumors, cardiovascular diseases, and organ development. However, in recent years, great progress has been made in elucidating the role of SPRED proteins in neuropsychiatric, inflammatory, endocrine, and ophthalmic diseases. This article provides a review of the experimental studies performed in recent years on the SPRED proteins and their role in the pathogenesis of certain diseases.
摘要：
2001年发现了与Sprouty相关的Ena/血管扩张剂刺激的磷蛋白同源性-1（EVH-1）结构域（SPRED）蛋白家族。这些与Sprouty相关的酪氨酸激酶结合蛋白负调节多种生长因子诱导的Ras/ERK信号通路。近年来,已经发现SPRED蛋白调节细胞发育等生命活动，运动,和扩散，并参与病理生理过程，如肿瘤转移，造血调节，和过敏反应。这些研究的发现对于SPRED蛋白在疾病中的参与具有重要意义。SPRED蛋白的早期研究主要集中在各种肿瘤上，心血管疾病,和器官发育。然而,近年来,在阐明SPRED蛋白在神经精神病学中的作用方面取得了很大进展，炎症，内分泌，和眼科疾病。本文综述了近年来有关SPRED蛋白及其在某些疾病发病机制中的作用的实验研究。
