Risk of Mitral Valve Prolapse in Patients with Keratoconus in Taiwan: A Population-Based Cohort Study.

• 影响指数: 4.614
• 发表时间: 08 2020 20
• 来源期刊: Int J Environ Res Public Health
• DOI: 10.3390/ijerph17176049
• PMID: 32825286
• 文章类型: Journal Article
• 作者列表: Chang YS,Tai MC,Weng SF,Wang JJ,Tseng SH,Jan RL

关键词: Taiwan Longitudinal Health Insurance Database; keratoconus; mitral valve prolapse

Mesh: Adolescent; Adult; Child; Cohort Studies; Female; Humans; Incidence; Keratoconus / complications epidemiology; Male; Mitral Valve Prolapse / complications epidemiology; Population; Retrospective Studies; Risk Factors; Taiwan / epidemiology; Young Adult

Abstract

This retrospective, nationwide, matched-cohort study included 4488 new-onset keratoconus (KCN) patients, ≥12 years old, recruited between 2004 and 2011 from the Taiwan National Health Insurance Research Database. The control group included 26,928 non-KCN patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Information for each patient was collected and tracked from the index date until December 2013. The incidence rate of mitral valve prolapse (MVP) was 1.77 times (95% confidence interval (CI) = 1.09-2.88; p = 0.0206) higher in KCN patients ≥40 years old and 1.49 times (95% CI = 1.12-1.98; p = 0.0060) higher in female KCN patients than in controls. After using the Cox proportional hazard regression analysis to adjust for potential confounders, including hypertension, hyperlipidemia, and congestive heart failure, KCN maintained an independent risk factor, MVP being 1.77 times (adjusted hazard ratio (HR) = 1.77, 95% CI = 1.09-2.88) and 1.48 times (adjusted HR = 1.48, 95% CI = 1.11-1.97) more likely to develop in patients ≥40 years old and female patients in the study cohort, respectively. We found that KCN patients ≥40 years of age and female KCN patients have increased risks of MVP. Therefore, it is recommended that KCN patients should be alerted to MVP.