荔枝籽多酚通过 LRP1 / AMPK 介导的自噬诱导抑制 A β 诱导的 NLRP3 炎性体活化.
关键词: 4',6-Diamidino-2-phenylindole (PubChem CID: 2954) AICAR (PubChem CID: 266934) Alzheimer's disease Autophagy Aβ(1-42) Bafilomycin A1 (PubChem CID: 6436223) Compound C (PubChem CID: 11524144) LRP1/AMPK LY294002 (PubChem CID: 3973) Lychee seed polyphenol NLRP3 inflammasome Rapamycin (PubChem CID: 5284616) SBI-0206965 (PubChem CID: 92044402) Thiazolyl blue (PubChem CID: 64965)
Mesh : AMP-Activated Protein Kinases / metabolism Alzheimer Disease / drug therapy metabolism Amyloid beta-Peptides Animals Autophagy / drug effects Cell Line Disease Models, Animal Inflammasomes / antagonists & inhibitors metabolism Litchi Low Density Lipoprotein Receptor-Related Protein-1 / genetics metabolism Male Maze Learning / drug effects Mice, Inbred C57BL Mice, Transgenic NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors metabolism Neuroprotective Agents / pharmacology Peptide Fragments Polyphenols / pharmacology RNA, Small Interfering Rats Seeds
来 源:
DOI:10.1016/j.biopha.2020.110575
PDF(Sci-hub)