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Abstract：
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.
摘要：
本文提供了进行孟德尔随机化研究的指南。它的目标是寻求进行分析并写下他们的发现的从业者，以及寻求评估孟德尔随机化手稿的期刊编辑和审稿人。指南分为九个部分：动机和范围，数据源,遗传变异的选择，变体协调，初步分析,补充和敏感性分析(一节关于稳健的统计方法，一节关于其他方法)，数据呈现,和解释。这些准则将根据社区的反馈和该领域的进展进行更新。将根据需要定期进行更新，至少每18个月。
