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Abstract：
Higher levels of ceramides have been linked to several chronic diseases; also there is emerging cross-sectional evidence that ceramides are associated with lower physical functioning. This research assessed for the first time the prospective relationship between ceramide species and impaired lower-extremity function (ILEF) in older adults.
Case-control study with 43 cases of ILEF and 86 age- and sex-matched controls, which was nested in the Seniors-ENRICA cohort of community-dwelling older adults. Incident ILEF from 2015 to 2017 was ascertained with the Short Physical Performance Battery. In 2015, 27 ceramide species were measured in plasma by liquid chromatography-tandem mass spectrometry. Conditional logistic regression models were used to assess the longitudinal relationship between ceramides concentration and incidence of ILEF.
After adjusting for education level, body mass index, alcohol and total energy intake, physical activity, and presence of chronic conditions, some ceramide species were related to 2-year incidence of ILEF. Specifically, the odds ratios of ILEF per 1-SD increase in ceramide concentration were: 1.66 [95% CI = (1.03, 2.68)] for ceramide C14:0, 1.61 (1.00, 2.59) for ceramide C16:0, and 1.64 (1.03, 2.60) for ceramide C16:1 (n-7). In the case of ceramides C16:0 and C16:1 (n-7), a stronger relationship was found in those with a higher body mass index; systolic blood pressure could also mediate the relationship between ceramide C16:1 (n-7) and ILEF (p for interaction = .03).
Higher plasma levels of ceramides C14:0, C16:0, and C16:1 (n-7) are associated with higher risk of ILEF, and might serve as risk markers for functional decline in older adults.
Case-control study with 43 cases of ILEF and 86 age- and sex-matched controls, which was nested in the Seniors-ENRICA cohort of community-dwelling older adults. Incident ILEF from 2015 to 2017 was ascertained with the Short Physical Performance Battery. In 2015, 27 ceramide species were measured in plasma by liquid chromatography-tandem mass spectrometry. Conditional logistic regression models were used to assess the longitudinal relationship between ceramides concentration and incidence of ILEF.
After adjusting for education level, body mass index, alcohol and total energy intake, physical activity, and presence of chronic conditions, some ceramide species were related to 2-year incidence of ILEF. Specifically, the odds ratios of ILEF per 1-SD increase in ceramide concentration were: 1.66 [95% CI = (1.03, 2.68)] for ceramide C14:0, 1.61 (1.00, 2.59) for ceramide C16:0, and 1.64 (1.03, 2.60) for ceramide C16:1 (n-7). In the case of ceramides C16:0 and C16:1 (n-7), a stronger relationship was found in those with a higher body mass index; systolic blood pressure could also mediate the relationship between ceramide C16:1 (n-7) and ILEF (p for interaction = .03).
Higher plasma levels of ceramides C14:0, C16:0, and C16:1 (n-7) are associated with higher risk of ILEF, and might serve as risk markers for functional decline in older adults.
摘要：
较高水平的神经酰胺与几种慢性疾病有关;也有新出现的横断面证据表明神经酰胺与较低的身体机能有关。这项研究首次评估了神经酰胺种类与老年人下肢功能受损（ILEF）之间的前瞻性关系。
病例对照研究，包括43例ILEF和86例年龄和性别匹配的对照，嵌套在社区居住老年人的老年人-ENRICA队列中。2015年至2017年的ILEF事件是通过短物理性能电池确定的。2015年，通过液相色谱-串联质谱法测量了血浆中的27种神经酰胺。使用条件逻辑回归模型来评估神经酰胺浓度与ILEF发生率之间的纵向关系。
在调整教育水平后，身体质量指数,酒精和总能量摄入，身体活动,和慢性病的存在，一些神经酰胺种类与ILEF的2年发病率相关.具体来说,神经酰胺浓度每1-SD增加ILEF的比值比分别为:神经酰胺C14:0为1.66[95%CI=(1.03,2.68)],神经酰胺C16:0为1.61(1.00,2.59),神经酰胺C16:1(n-7)为1.64(1.03,2.60).在神经酰胺C16：0和C16：1（n-7）的情况下，在体重指数较高的人群中发现了更强的关系;收缩压也可以介导神经酰胺C16:1(n-7)和ILEF之间的关系(p表示相互作用=.03).
较高的血浆神经酰胺C14：0，C16：0和C16：1（n-7）水平与较高的ILEF风险相关，并可能作为老年人功能下降的风险标志物。
病例对照研究，包括43例ILEF和86例年龄和性别匹配的对照，嵌套在社区居住老年人的老年人-ENRICA队列中。2015年至2017年的ILEF事件是通过短物理性能电池确定的。2015年，通过液相色谱-串联质谱法测量了血浆中的27种神经酰胺。使用条件逻辑回归模型来评估神经酰胺浓度与ILEF发生率之间的纵向关系。
在调整教育水平后，身体质量指数,酒精和总能量摄入，身体活动,和慢性病的存在，一些神经酰胺种类与ILEF的2年发病率相关.具体来说,神经酰胺浓度每1-SD增加ILEF的比值比分别为:神经酰胺C14:0为1.66[95%CI=(1.03,2.68)],神经酰胺C16:0为1.61(1.00,2.59),神经酰胺C16:1(n-7)为1.64(1.03,2.60).在神经酰胺C16：0和C16：1（n-7）的情况下，在体重指数较高的人群中发现了更强的关系;收缩压也可以介导神经酰胺C16:1(n-7)和ILEF之间的关系(p表示相互作用=.03).
较高的血浆神经酰胺C14：0，C16：0和C16：1（n-7）水平与较高的ILEF风险相关，并可能作为老年人功能下降的风险标志物。
