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Abstract：
BACKGROUND: The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused countries all over the world to impose lockdowns and undertake stringent preventive measures. This new positive-sense single-stranded RNA strain of coronavirus spreads through droplets of saliva and nasal discharge.
OBJECTIVE: US FDA has authorized the emergency use of Remdesivir looking at the increasing number of cases of COVID-19, however there is still no drug approved to treat COVID-19. An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties.
METHODS: We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea and theaflavins from black tea. Both green tea and black tea polyphenols have been reported to exhibit antiviral activities against various viruses, especially positive-sense single-stranded RNA viruses.
RESULTS: Recent studies have revealed the possible binding sites present on SARS-CoV-2 and studied their interactions with tea polyphenols. EGCG and theaflavins, especially theaflavin-3,3\'-digallate (TF3) have shown a significant interaction with the receptors under consideration in this review. Some docking studies further emphasize on the activity of these polyphenols against COVID-19.
CONCLUSIONS: This review summarizes the available reports and evidences which support the use of tea polyphenols as potential candidates in prophylaxis and treatment of COVID-19.
OBJECTIVE: US FDA has authorized the emergency use of Remdesivir looking at the increasing number of cases of COVID-19, however there is still no drug approved to treat COVID-19. An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties.
METHODS: We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea and theaflavins from black tea. Both green tea and black tea polyphenols have been reported to exhibit antiviral activities against various viruses, especially positive-sense single-stranded RNA viruses.
RESULTS: Recent studies have revealed the possible binding sites present on SARS-CoV-2 and studied their interactions with tea polyphenols. EGCG and theaflavins, especially theaflavin-3,3\'-digallate (TF3) have shown a significant interaction with the receptors under consideration in this review. Some docking studies further emphasize on the activity of these polyphenols against COVID-19.
CONCLUSIONS: This review summarizes the available reports and evidences which support the use of tea polyphenols as potential candidates in prophylaxis and treatment of COVID-19.
摘要：
背景：新型冠状病毒SARS-CoV-2或nCoV的迅速传播导致世界各国实施封锁并采取严格的预防措施。冠状病毒的这种新的正义单链RNA毒株通过唾液和鼻腔分泌物的液滴传播。
目的：美国FDA已授权紧急使用Remdesivir，以应对不断增加的COVID-19病例，但仍没有批准治疗COVID-19的药物。另一种治疗方法可以是使用具有已知抗病毒性质的天然衍生分子。
方法：我们综述了两种茶多酚的抗病毒活性，绿茶中的表没食子儿茶素-3-没食子酸酯（EGCG）和红茶中的茶黄素。据报道，绿茶和红茶多酚对各种病毒都表现出抗病毒活性，尤其是正义单链RNA病毒。
结果：最近的研究揭示了SARS-CoV-2上可能存在的结合位点，并研究了它们与茶多酚的相互作用。EGCG和茶黄素,特别是茶黄素-3,3'-二烷基酯（TF3）已显示出与本评论中考虑的受体的显着相互作用。一些对接研究进一步强调了这些多酚对COVID-19的活性。
结论：本综述总结了支持使用茶多酚作为预防和治疗COVID-19的潜在候选药物的现有报告和证据。
目的：美国FDA已授权紧急使用Remdesivir，以应对不断增加的COVID-19病例，但仍没有批准治疗COVID-19的药物。另一种治疗方法可以是使用具有已知抗病毒性质的天然衍生分子。
方法：我们综述了两种茶多酚的抗病毒活性，绿茶中的表没食子儿茶素-3-没食子酸酯（EGCG）和红茶中的茶黄素。据报道，绿茶和红茶多酚对各种病毒都表现出抗病毒活性，尤其是正义单链RNA病毒。
结果：最近的研究揭示了SARS-CoV-2上可能存在的结合位点，并研究了它们与茶多酚的相互作用。EGCG和茶黄素,特别是茶黄素-3,3'-二烷基酯（TF3）已显示出与本评论中考虑的受体的显着相互作用。一些对接研究进一步强调了这些多酚对COVID-19的活性。
结论：本综述总结了支持使用茶多酚作为预防和治疗COVID-19的潜在候选药物的现有报告和证据。
