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Abstract：
OBJECTIVE: To investigate photoreceptor degeneration in retinitis pigmentosa (RP) by quantitatively analysing optical intensity of ellipsoid zone (EZ) on optical coherence tomography (OCT).
METHODS: We conducted OCT line scans of the horizontal meridian in 24 eyes of 24 RP patients and 30 eyes of 30 healthy controls and obtained longitudinal reflectance profiles using ImageJ at every 5 pixels. Relative optical intensity was calculated from dividing the peak of EZ by the mean of the whole retina.
RESULTS: The optical intensity of EZ variation followed a similar pattern in all patients. It decreased with eccentricity and then vanished, regardless whether it was normal or reduced at the fovea. The mean relative optical intensity of EZ in RP patients was 0.69 ± 0.13 to that of control subjects at the location just before it disappeared. The relative optical intensity of EZ at fovea was significantly correlated with the best-corrected visual acuity in patients (r = -0.617, p = 0.001).
CONCLUSIONS: The optical intensity of EZ detected by OCT can serve as a biomarker for early detection of photoreceptor degeneration in RP.
METHODS: We conducted OCT line scans of the horizontal meridian in 24 eyes of 24 RP patients and 30 eyes of 30 healthy controls and obtained longitudinal reflectance profiles using ImageJ at every 5 pixels. Relative optical intensity was calculated from dividing the peak of EZ by the mean of the whole retina.
RESULTS: The optical intensity of EZ variation followed a similar pattern in all patients. It decreased with eccentricity and then vanished, regardless whether it was normal or reduced at the fovea. The mean relative optical intensity of EZ in RP patients was 0.69 ± 0.13 to that of control subjects at the location just before it disappeared. The relative optical intensity of EZ at fovea was significantly correlated with the best-corrected visual acuity in patients (r = -0.617, p = 0.001).
CONCLUSIONS: The optical intensity of EZ detected by OCT can serve as a biomarker for early detection of photoreceptor degeneration in RP.
摘要：
目的：通过光学相干断层扫描（OCT）定量分析椭球区（EZ）的光强度，研究视网膜色素变性（RP）的光感受器变性。
方法：我们对24名RP患者的24只眼和30名健康对照者的30只眼进行了水平子午线的OCT线扫描，并使用ImageJ在每5个像素处获得纵向反射图。通过将EZ的峰除以整个视网膜的平均值来计算相对光强度。
结果：在所有患者中，EZ变异的光强度遵循相似的模式。随着偏心率的减少，然后消失了，无论在中央凹是正常的还是缩小的。RP患者中EZ的平均相对光强度为0.69±0.13，而对照组在其消失之前的位置。EZ在中央凹的相对光强度与患者的最佳矫正视力显着相关（r=-0.617，p=0.001）。
结论：通过OCT检测的EZ的光强度可以作为早期检测RP中光感受器变性的生物标志物。
方法：我们对24名RP患者的24只眼和30名健康对照者的30只眼进行了水平子午线的OCT线扫描，并使用ImageJ在每5个像素处获得纵向反射图。通过将EZ的峰除以整个视网膜的平均值来计算相对光强度。
结果：在所有患者中，EZ变异的光强度遵循相似的模式。随着偏心率的减少，然后消失了，无论在中央凹是正常的还是缩小的。RP患者中EZ的平均相对光强度为0.69±0.13，而对照组在其消失之前的位置。EZ在中央凹的相对光强度与患者的最佳矫正视力显着相关（r=-0.617，p=0.001）。
结论：通过OCT检测的EZ的光强度可以作为早期检测RP中光感受器变性的生物标志物。
