Evolution and Antigenic Drift of Influenza A (H7N9) Viruses, China, 2017-2019.

甲型流感病毒 （ H7N9 ） 的进化和抗原漂移 ，中国,2017 - 2019 年。

• 影响指数: 16.126
• 发表时间: 08 2020
• 来源期刊: Emerg Infect Dis
• DOI: 10.3201/eid2608.200244
• PMID: 32687047
• 文章类型: Journal Article
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Zhang J,Ye H,Li H,Ma K,Qiu W,Chen Y,Qiu Z,Li B,Jia W,Liang Z,Liao M,Qi W

关键词: China; H7N9 viruses; HPAI; antigenic drift; evolution; high pathogenicity; highly pathogenic avian influenza; influenza; influenza virus; low pathogenicity; viruses

Mesh: Animals; China / epidemiology; Hemagglutinin Glycoproteins, Influenza Virus / genetics; Influenza A Virus, H7N9 Subtype / genetics; Influenza in Birds; Influenza, Human / epidemiology

Abstract

After a sharp decrease of influenza A(H7N9) virus in China in 2018, highly pathogenic H7N9 viruses re-emerged in 2019. These H7N9 variants exhibited a new predominant subclade and had been cocirculating at a low level in eastern and northeastern China. Several immune escape mutations and antigenic drift were observed in H7N9 variants.

摘要

在2018年中国甲型H7N9流感病毒大幅减少后，2019年高致病性H7N9病毒重新出现。这些H7N9变体表现出一个新的主要亚进化枝，并且在中国东部和东北地区一直处于低水平。在H7N9变体中观察到几种免疫逃逸突变和抗原漂移。