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Abstract：
B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen-presenting cells for CD4+ and CD8+ T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and contribute to virus persistence. Recent work has uncovered a role for B cells in the induction and activation of Tregs during FV infection. In addition to inducing Tregs, B cell antibody production and antigen-presenting cell activity is a target of Treg suppression. This review focuses on the dynamic interactions between B cells and Tregs during FV infection.
摘要：
B淋巴细胞在病毒感染期间具有良好的效应子作用，包括抗体的产生和作为CD4+和CD8+T细胞的抗原呈递细胞的功能。B细胞也已显示出调节免疫应答和诱导调节性T细胞(Tregs)。在朋友病毒(FV)模型中,已知Treg抑制效应CD8+T细胞应答并有助于病毒持久性。最近的工作揭示了B细胞在FV感染期间Treg的诱导和激活中的作用。除了诱导Tregs，B细胞抗体产生和抗原呈递细胞活性是Treg抑制的目标。本文综述了FV感染过程中B细胞与Tregs之间的动态相互作用。
