%0 Journal Article
%T B-Cell Control of Regulatory T Cells in Friend Virus Infection.
%A Moore TC
%A Hasenkrug KJ
%J J Mol Biol
%V 433
%N 1
%D 01 2021 8
%M 32598936
%F 6.151
%R 10.1016/j.jmb.2020.06.022
%X B lymphocytes have well-established effector roles during viral infections, including production of antibodies and functioning as antigen-presenting cells for CD4+ and CD8+ T cells. B cells have also been shown to regulate immune responses and induce regulatory T cells (Tregs). In the Friend virus (FV) model, Tregs are known to inhibit effector CD8+ T-cell responses and contribute to virus persistence. Recent work has uncovered a role for B cells in the induction and activation of Tregs during FV infection. In addition to inducing Tregs, B cell antibody production and antigen-presenting cell activity is a target of Treg suppression. This review focuses on the dynamic interactions between B cells and Tregs during FV infection.