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Abstract：
The lack of effective treatment for chronic discomfort without negative side effects highlights the need for alternative treatments. Pain Bloc-R is a natural health product composed of vitamins B6, B12, D, white willow bark extract, Angelica root extract, acetyl L-carnitine HCl, caffeine, L-theanine, Benfotiamine, and L-tetrahydropalmatine. The objective of this study was to compare the effects of Pain Bloc-R, acetaminophen, and placebo on unresolved aches and discomfort as assessed by the brief pain inventory (BPI) and modified Cornell musculoskeletal discomfort questionnaires. This randomized, double-blind, placebo-controlled, crossover study consisted of three 7-day periods with Pain Bloc-R, acetaminophen, or placebo, each separated by a 7-day washout. Twenty-seven healthy adults (ages 22-63 years) were randomized to receive the three interventions in different sequences. The BPI \"pain at its worst\" scores were significantly lower when participants took Pain Bloc-R than when they took acetaminophen (21.8% vs. 9.8% decrease, p = 0.026) after seven days of supplementation. Pain Bloc-R achieved a significant improvement in the \"pain at its least\" score, significantly decreased the interference of discomfort in walking, and significantly decreased musculoskeletal discomfort total scores (34%, p = 0.040) after seven days. In a post hoc subgroup analysis based on age and gender, male participants ≤45 years taking Pain Bloc-R reported significant reductions in pain severity and pain interference vs. acetaminophen. Pain Bloc-R performed as well as acetaminophen in managing unresolved non-pathological pain in otherwise healthy individuals.
摘要：
缺乏对慢性不适的有效治疗而没有负面副作用突出了对替代疗法的需要。疼痛Bloc-R是一种由维生素B6，B12，D，白柳树皮提取物，当归根提取物，乙酰L-肉碱HCl,咖啡因,L-茶氨酸,苯福硫胺,和L-四氢巴马汀.这项研究的目的是比较疼痛Bloc-R的效果，对乙酰氨基酚,通过简短的疼痛清单（BPI）和改良的康奈尔肌肉骨骼不适问卷评估，以及安慰剂对未解决的疼痛和不适的治疗。这个随机的，双盲,安慰剂对照,交叉研究包括三个为期7天的疼痛Bloc-R，对乙酰氨基酚,或安慰剂，每个人都被7天的冲洗分开。27名健康成年人（22-63岁）随机接受不同顺序的三种干预措施。参与者服用PainBloc-R时的BPI“疼痛最差”分数显着低于服用对乙酰氨基酚时（21.8％vs.下降9.8%,补充7天后p=0.026）。疼痛Bloc-R在“至少疼痛”评分方面取得了显着改善，显著减少了行走中不适的干扰，肌肉骨骼不适总分显著降低(34%，七天后p=0.040）。在基于年龄和性别的事后分组分析中，男性参与者≤45年服用疼痛Bloc-R报告疼痛严重程度和疼痛干扰显著降低。对乙酰氨基酚.疼痛Bloc-R在其他健康个体中未解决的非病理性疼痛中的表现与对乙酰氨基酚一样。
