METHODS: This nationwide, retrospective, matched cohort study included 186 202 newly diagnosed AKC patients who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), code 372.05, and selected from the Taiwan National Health Insurance Research Database. The age- and sex-matched control group included 186 202 non-AKC patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Patient information was collected between 1 January 2004 and 31 December 2011, and both groups of patients were tracked from the index date until December 2013. The incidence and risk of KCN (ICD-9-CM, code 371.6) were compared between the groups. A Cox proportional hazard regression analysis was performed to obtain the adjusted hazard ratio (HR) for KCN. The cumulative KCN incidence rate was calculated with the Kaplan-Meier analysis.
RESULTS: In total, 62 AKC patients and 26 controls developed KCN during the follow-up period. The incidence rate of KCN was 2.49 times (95% confidence interval [CI] = 1.57-3.93; p < 0.0001) higher in AKC patients than in controls. After adjusting for potential confounders, AKC patients were 2.25 times more likely to develop KCN than controls (adjusted HR, 2.25; 95% CI = 1.41-3.58; p < 0.05).
CONCLUSIONS: Atopic keratoconjunctivitis (AKC) patients had an increased risk of developing KCN. Therefore, AKC patients should be advised of this risk.
方法:全国范围内,回顾性,配对队列研究包括186.202例新诊断的AKC患者,这些患者是由国际疾病分类鉴定的,第九次修订,临床修改(ICD-9-CM),代码372.05,并从台湾国民健康保险研究数据库中选取。年龄和性别匹配的对照组包括从台湾纵向健康保险数据库2000中选择的186.202名非AKC患者。在2004年1月1日至2011年12月31日期间收集患者信息,从索引日期到2013年12月对两组患者进行跟踪。KCN的发生率和风险(ICD-9-CM,编号371.6)进行组间比较。进行Cox比例风险回归分析以获得KCN的校正风险比(HR)。用Kaplan-Meier分析计算累积KCN发生率。
结果:总计,62名AKC患者和26名对照在随访期间出现KCN。AKC患者的KCN发生率为对照组的2.49倍(95%置信区间[CI]=1.57-3.93;p<0.0001)。在调整了潜在的混杂因素后,AKC患者发生KCN的可能性是对照组的2.25倍(调整后的HR,2.25;95%CI=1.41-3.58;p<0.05)。
结论:异位性角膜结膜炎(AKC)患者发生KCN的风险增加。因此,应告知AKC患者这种风险。