PDF(Sci-hub)
Abstract：
OBJECTIVE: To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.
UNASSIGNED: The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.
RESULTS: A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.
CONCLUSIONS: T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.
UNASSIGNED: The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.
RESULTS: A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.
CONCLUSIONS: T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.
摘要：
目的：探讨内皮型一氧化氮合酶(eNOS)4VNTR和G894T基因多态性可介导西班牙人的雄激素治疗反应。
■研究参与者是在疼痛科招募的患有勃起功能障碍（ED）和慢性疼痛（n=105）的西班牙人男性。使用Taqman特异性探针通过定量聚合酶链反应对eNOS多态性进行基因分型。采用R-3.2.4软件进行统计学分析。
结果：共有69例患者需要进行雄激素治疗，其中76％的患者在iPED5（20％）后ED得到改善，睾酮（35％）或iPDE5/睾酮治疗（45％）；在T786C-CC患者中明显更好。多元回归分析表明,年龄,阿片类药物每日剂量和T786C-C等位基因携带影响西班牙人慢性疼痛患者的风险和ED严重程度。
结论：eNOS位点的T786C多态性似乎是西班牙人勃起功能iPDE5/睾酮反应的主要因素。
■研究参与者是在疼痛科招募的患有勃起功能障碍（ED）和慢性疼痛（n=105）的西班牙人男性。使用Taqman特异性探针通过定量聚合酶链反应对eNOS多态性进行基因分型。采用R-3.2.4软件进行统计学分析。
结果：共有69例患者需要进行雄激素治疗，其中76％的患者在iPED5（20％）后ED得到改善，睾酮（35％）或iPDE5/睾酮治疗（45％）；在T786C-CC患者中明显更好。多元回归分析表明,年龄,阿片类药物每日剂量和T786C-C等位基因携带影响西班牙人慢性疼痛患者的风险和ED严重程度。
结论：eNOS位点的T786C多态性似乎是西班牙人勃起功能iPDE5/睾酮反应的主要因素。
