%0 Journal Article
%T Endothelial nitric oxide synthase gene polymorphisms and erectile dysfunction in chronic pain.
%A Segura A
%A Ballester P
%A Ajo R
%A Inda MD
%A Urbano A
%A Muriel J
%A Ochando I
%A Margarit C
%A Martinez E
%A Peiró AM
%J Gene X
%V 1
%N 0
%D Feb 2019
%M 32550542
暂无%R 10.1016/j.gene.2019.100005
%X OBJECTIVE: To investigate whether endothelial nitric oxide synthase (eNOS) T786C, 4VNTR and G894 T gene polymorphisms could mediate in andrological treatment response in Spaniards.
UNASSIGNED: The study participants were Spaniard males with erectile dysfunction (ED) and chronic pain (n = 105) recruited at the Pain Unit. eNOS polymorphisms were genotyped by quantitative polymerase chain reaction using Taqman specific probes. Statistical analyses were carried out using R-3.2.4 software.
RESULTS: A total of 69 patients required andrological treatment and 76% of them improved ED upon iPED5 (20%), testosterone (35%) or iPDE5/testosterone treatment (45%); being significantly better in T786C-CC patients. Multivariate regression analysis indicated that age, opioid daily dose and carriage of T786C-C allele influenced the risk and ED severity in Spaniard chronic pain patients.
CONCLUSIONS: T786C polymorphism at eNOS locus appeared to be a major contributor in the variable erectile function iPDE5/testosterone response in Spaniards.