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Abstract：
The grain structure and surface morphology of bio-implants act as a pivotal part in altering cell behavior. Titanium alloy bone screws, as common implants, are prone to screws loosening and complications threat in the physiological environment due to their inferior anti-wear and surface inertia. Manufacturing bone screws with high wear resistance and ideal biocompatibility has always been a challenge. In this study, a series of overlapping morphologies inspired by the hierarchical structure of fish scales and micro bulges of shrimp were structured on Ti-6Al-4V implant by laser texturing. The results indicate that the textured patterns could improve cell attachment, proliferation, and osteogenic differentiation. The short-term response of human bone marrow-derived mesenchymal stem cells (hBMSCs) on the textured surface are more sensitive to the microstructure than the surface roughness, wettability, grain size and surface chemical elements of the textured surfaces. More importantly, the friction-increasing and friction-reducing type overlapping structures exhibit excellent friction stability at different stages of modified simulated body fluid (m-SBF) soaking. The overlapping structure (Micro-smooth stacked ring: MSSR) is more beneficial to promote the formation of apatite. Deposited spherical-like apatite particles can act as a \"lubricant\" on the MSSR surface during the friction process to alleviate the adhesion wear of the surface. Meanwhile, apatite particles participate in the formation of friction film, which plays an effective role in reducing friction and antiwear in corrosion solution (m-SBF) for a long time. These features show that the combination of soaking treatment in m-SBF solution with laser-textured MSSR structure is expected to be an efficient and environmentally friendly strategy to prolong the service life of bone screws and reducing the complications of mildly osteoporotic implants.
摘要：
生物植入物的颗粒结构和表面形态是改变细胞行为的关键部分。钛合金骨螺钉,作为常见的植入物，在生理环境中，由于其抗磨损性差和表面惯性，容易出现螺钉松动和并发症威胁。制造具有高耐磨性和理想生物相容性的骨螺钉一直是一个挑战。在这项研究中,通过激光纹理在Ti-6Al-4V植入物上构造了一系列重叠的形态，这些形态受鱼鳞的层次结构和虾的微凸起的启发。结果表明，纹理图案可以改善细胞附着，扩散,和成骨分化。人骨髓间充质干细胞（hBMSCs）在纹理表面的短期反应比表面粗糙度对微观结构更敏感，润湿性,纹理表面的晶粒尺寸和表面化学元素。更重要的是,在改性模拟体液（m-SBF）浸泡的不同阶段，增加摩擦和减少摩擦型重叠结构表现出优异的摩擦稳定性。重叠结构(微光滑堆叠环:MSSR)更有利于促进磷灰石的形成。在摩擦过程中，沉积的球形磷灰石颗粒可以在MSSR表面上充当“润滑剂”，以减轻表面的粘附磨损。同时,磷灰石颗粒参与摩擦膜的形成，长期在腐蚀溶液（m-SBF）中起到有效的减摩抗磨作用。这些特征表明，在m-SBF溶液中浸泡处理与激光纹理化MSSR结构相结合有望成为一种有效且环保的策略，以延长骨螺钉的使用寿命并减少轻度骨质疏松植入物的并发症。
