关键词: Folate receptor Heteroatom bridge Pyrrolo[2,3-d]pyrimidine Reduced folate carrier Selective uptake
Mesh : Animals Antineoplastic Agents / chemical synthesis metabolism pharmacology Binding Sites CHO Cells Catalytic Domain Cell Line, Tumor Cricetinae Cricetulus Drug Design Folate Receptor 1 / chemistry genetics metabolism Folate Receptor 2 / chemistry genetics metabolism Folic Acid / chemistry metabolism Folic Acid Antagonists / chemical synthesis metabolism pharmacology Humans Molecular Docking Simulation Phosphoribosylglycinamide Formyltransferase / chemistry metabolism Pyrimidines / chemistry metabolism pharmacology Pyrroles / chemistry metabolism pharmacology Structure-Activity Relationship
来 源:
DOI:10.1016/j.bmc.2020.115544
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