编码 ChAT 基因的人神经干细胞通过乙酰胆碱合成恢复认知功能,A β 消除,和 APPswe / PS1dE9 小鼠的神经再生。
关键词: Alzheimer disease Aβ deposition acetylcholine choline acetyltransferase human neural stem cell neuroregeneration
Mesh : Acetylcholine / biosynthesis Amyloid beta-Peptides / metabolism Amyloid beta-Protein Precursor / genetics Animals Astrocytes / metabolism Brain / metabolism Cell Proliferation Cell- and Tissue-Based Therapy Choline O-Acetyltransferase / metabolism Cognition Cognition Disorders / therapy Hippocampus / metabolism Humans Memory Disorders / metabolism Mice Mice, Transgenic Microglia / metabolism Nerve Growth Factors / metabolism Neural Stem Cells / cytology metabolism Neurons / metabolism Presenilin-1 / genetics Receptors, Cholinergic / metabolism Regeneration
来 源:
DOI:10.3390/ijms21113958
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