PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the significance of acute disulfiram poisoning in pediatric population.
UNASSIGNED: Disulfiram poisoning in children is uncommon, can occur in children who have ingested large amount of drug because of careless and unsafe storage. Only few cases have been reported in literature. Although well tolerated by most patients, severe toxic side effects have been also reported including hepatitis, encephalopathy, psychosis, optic, and peripheral neuropathy.
UNASSIGNED: This is a case report of disulfiram toxicity in a 4.5-year girl who ingested 4-5 tablets of disulfiram (approximately 1-1.25 g) accidentally and presented with hypoglycemia and encephalopathy. After initial stabilization in emergency room, the child was shifted to intensive care unit (ICU) where the child was managed conservatively. Blood sugars normalized after 8 hours of admission. Magnetic resonance imaging (MRI) brain showed bilateral globus pallidus hyperintensity in T2-weighted (T2W) and diffusion-weighted (DW) images and hypointensity in T1-weighted (T1W) images including diffusion restriction.
UNASSIGNED: Acute disulfiram poisoning can occur in children who have ingested large amount of drug because of unsafe storage. It can lead to hepatitis, encephalopathy, psychosis, optic, and peripheral neuropathy. Mainstay of treatment is supportive care, airway protection, oxygen, and dextrose-containing intravenous fluid should be given.
UNASSIGNED: Acute disulfiram poisoning should be an important differential in diagnosis of any child presenting with idiopathic encephalopathy along with extrapyramidal symptoms with basal ganglia signal changes in MRI of brain in a previously healthy child.
UNASSIGNED: Bhalla K, Mittal K, Gupta A, Nehra D. Acute Disulfiram Poisoning in a Child: A Case Report and Review of Literature. Indian J Crit Care Med 2020;24(3):203-205.
UNASSIGNED: Disulfiram poisoning in children is uncommon, can occur in children who have ingested large amount of drug because of careless and unsafe storage. Only few cases have been reported in literature. Although well tolerated by most patients, severe toxic side effects have been also reported including hepatitis, encephalopathy, psychosis, optic, and peripheral neuropathy.
UNASSIGNED: This is a case report of disulfiram toxicity in a 4.5-year girl who ingested 4-5 tablets of disulfiram (approximately 1-1.25 g) accidentally and presented with hypoglycemia and encephalopathy. After initial stabilization in emergency room, the child was shifted to intensive care unit (ICU) where the child was managed conservatively. Blood sugars normalized after 8 hours of admission. Magnetic resonance imaging (MRI) brain showed bilateral globus pallidus hyperintensity in T2-weighted (T2W) and diffusion-weighted (DW) images and hypointensity in T1-weighted (T1W) images including diffusion restriction.
UNASSIGNED: Acute disulfiram poisoning can occur in children who have ingested large amount of drug because of unsafe storage. It can lead to hepatitis, encephalopathy, psychosis, optic, and peripheral neuropathy. Mainstay of treatment is supportive care, airway protection, oxygen, and dextrose-containing intravenous fluid should be given.
UNASSIGNED: Acute disulfiram poisoning should be an important differential in diagnosis of any child presenting with idiopathic encephalopathy along with extrapyramidal symptoms with basal ganglia signal changes in MRI of brain in a previously healthy child.
UNASSIGNED: Bhalla K, Mittal K, Gupta A, Nehra D. Acute Disulfiram Poisoning in a Child: A Case Report and Review of Literature. Indian J Crit Care Med 2020;24(3):203-205.
摘要：
■确定急性双硫仑中毒在儿科人群中的意义。
■儿童双硫仑中毒并不常见，可能发生在由于粗心和不安全的储存而摄入大量药物的儿童中。文献中只有少数病例报道。虽然大多数患者耐受性良好，还报告了严重的毒副作用，包括肝炎，脑病,精神病,光学的,和周围神经病变。
■这是一例双硫仑中毒的病例报告，一例4.5岁女孩意外摄入4-5片双硫仑（约1-1.25g），出现低血糖和脑病。在急诊室初步稳定后，儿童被转移到重症监护病房(ICU),在那里对儿童进行保守管理.入院8小时后血糖恢复正常。磁共振成像（MRI）在T2加权（T2W）和弥散加权（DW）图像中显示双侧苍白球高强度，在T1加权（T1W）图像中显示出包括弥散限制在内的低张力。
■急性双硫仑中毒可发生在因储存不安全而摄入大量药物的儿童中。它可以导致肝炎，脑病,精神病,光学的,和周围神经病变。治疗的主要手段是支持治疗,气道保护,氧气,应给予含葡萄糖的静脉输液。
■急性双硫仑中毒应该是诊断任何患有特发性脑病并伴有锥体外系症状的儿童的重要鉴别诊断。
■BhallaK,米塔尔K,古普塔A,儿童急性双硫仑中毒1例报告及文献复习.印度JCritCareMed2020；24（3）：203-205。
■儿童双硫仑中毒并不常见，可能发生在由于粗心和不安全的储存而摄入大量药物的儿童中。文献中只有少数病例报道。虽然大多数患者耐受性良好，还报告了严重的毒副作用，包括肝炎，脑病,精神病,光学的,和周围神经病变。
■这是一例双硫仑中毒的病例报告，一例4.5岁女孩意外摄入4-5片双硫仑（约1-1.25g），出现低血糖和脑病。在急诊室初步稳定后，儿童被转移到重症监护病房(ICU),在那里对儿童进行保守管理.入院8小时后血糖恢复正常。磁共振成像（MRI）在T2加权（T2W）和弥散加权（DW）图像中显示双侧苍白球高强度，在T1加权（T1W）图像中显示出包括弥散限制在内的低张力。
■急性双硫仑中毒可发生在因储存不安全而摄入大量药物的儿童中。它可以导致肝炎，脑病,精神病,光学的,和周围神经病变。治疗的主要手段是支持治疗,气道保护,氧气,应给予含葡萄糖的静脉输液。
■急性双硫仑中毒应该是诊断任何患有特发性脑病并伴有锥体外系症状的儿童的重要鉴别诊断。
■BhallaK,米塔尔K,古普塔A,儿童急性双硫仑中毒1例报告及文献复习.印度JCritCareMed2020；24（3）：203-205。
