日本肺动脉高压患者波生坦诱导肝毒性的预测模型。
关键词: CHST13 CHST3 bosentan hypertension artérielle pulmonaire pharmacogenomics pharmacogénomique pulmonary arterial hypertension
Mesh : Adult Aged Aged, 80 and over Alleles Bosentan / adverse effects pharmacokinetics Chemical and Drug Induced Liver Injury / blood epidemiology genetics pathology Creatinine / blood Endothelin Receptor Antagonists / adverse effects pharmacokinetics Female Humans Japan / epidemiology Liver / drug effects pathology Male Models, Statistical Mutation Pharmacogenomic Variants Polymorphism, Single Nucleotide Predictive Value of Tests Pulmonary Arterial Hypertension / blood drug therapy genetics Risk Assessment / methods Sulfotransferases / genetics metabolism Carbohydrate Sulfotransferases
来 源:
DOI:10.1139/cjpp-2019-0656
PDF(Sci-hub)