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Abstract：
BACKGROUND: We report the first case of transcranial magnetic resonance-guided focused ultrasound (MRgFUS) for mesial temporal lobe epilepsy (MTLE).
METHODS: The target was located 20 mm lateral from the midline and 15 mm above the skull base (left hippocampus). Despite the application of maximal energy, the ablation temperature did not exceed 50 °C, probably because of the low number of effective transducer elements with incident angles below 25 degrees. The skull density ratio was 0.56. Post-operative magnetic resonance imaging did not reveal any lesion and the patient remained almost seizure-free for up to 12 months.
CONCLUSIONS: This preliminary case report suggests that MRgFUS may be effective for treating cases of MTLE. Therefore, the safety and feasibility of MRgFUS should be evaluated in future studies with larger numbers of participants and longer follow-up duration.
METHODS: The target was located 20 mm lateral from the midline and 15 mm above the skull base (left hippocampus). Despite the application of maximal energy, the ablation temperature did not exceed 50 °C, probably because of the low number of effective transducer elements with incident angles below 25 degrees. The skull density ratio was 0.56. Post-operative magnetic resonance imaging did not reveal any lesion and the patient remained almost seizure-free for up to 12 months.
CONCLUSIONS: This preliminary case report suggests that MRgFUS may be effective for treating cases of MTLE. Therefore, the safety and feasibility of MRgFUS should be evaluated in future studies with larger numbers of participants and longer follow-up duration.
摘要：
背景：我们报告了首例经颅磁共振引导聚焦超声（MRgFUS）治疗内侧颞叶癫痫（MTLE）的病例。
方法：目标位于距中线20毫米外侧和颅底上方15毫米（左侧海马）。尽管应用了最大的能量，消融温度不超过50°C,可能是因为低数量的有效换能器元件的入射角低于25度。颅骨密度比为0.56。术后磁共振成像未发现任何病变，患者在长达12个月的时间内几乎没有癫痫发作。
结论：本初步病例报告提示MRgFUS治疗MTLE可能有效。因此,MRgFUS的安全性和可行性应在未来参与者数量更多,随访时间更长的研究中进行评估.
方法：目标位于距中线20毫米外侧和颅底上方15毫米（左侧海马）。尽管应用了最大的能量，消融温度不超过50°C,可能是因为低数量的有效换能器元件的入射角低于25度。颅骨密度比为0.56。术后磁共振成像未发现任何病变，患者在长达12个月的时间内几乎没有癫痫发作。
结论：本初步病例报告提示MRgFUS治疗MTLE可能有效。因此,MRgFUS的安全性和可行性应在未来参与者数量更多,随访时间更长的研究中进行评估.
