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Abstract：
Recently, two-dimensional transition metal dichalcogenides (2D TMDCs) have drawn certain attentions in many fields. The unique and diversified electronic structure and ultrathin sheet structure of 2D TMDCs offer opportunities for moving ahead of other 2D nanomaterials such as graphene and expanding the wide application of inorganic 2D nanomaterials in many fields. For a better understanding of 2D TMDCs, one needs to know methods for their synthesis and modification, as well as their potential applications and possible biological toxicity. Herein, we summarized the recent research progress of 2D TMDCs with particular focus on their biomedical applications and potential health risks. Firstly, two kinds of synthesis methods of 2D TMDCs, top-down and bottom-up, and methods for their surface functionalization are reviewed. Secondly, the applications of 2D TMDCs in the field of biomedicine, including drug loading, photothermal therapy, biological imaging and biosensor were summarized. After that, we presented the existing researches on biosafety evaluation of 2D TMDCs. At last, we discussed major research gap in current researches and challenges and coping strategies in future studies.
摘要：
最近,二维过渡金属二硫属化合物（2DTMDC）在许多领域引起了一定的关注。二维TMDC独特多样的电子结构和超薄的片状结构为推动石墨烯等其他二维纳米材料的发展、拓展无机二维纳米材料在诸多领域的广泛应用提供了契机。为了更好地理解2DTMDC，人们需要知道它们的合成和修饰方法，以及它们的潜在应用和可能的生物毒性。在这里，我们总结了2DTMDCs的最新研究进展，特别关注其生物医学应用和潜在的健康风险。首先,二维TMDC的两种合成方法，自上而下和自下而上，并对其表面功能化的方法进行了综述。其次,二维TMDC在生物医学领域的应用，包括药物装载，光热疗法,对生物成像和生物传感器进行了综述。之后,我们介绍了2DTMDCs生物安全性评价的现有研究。最后,我们讨论了当前研究的主要研究差距以及未来研究面临的挑战和应对策略。
