PDF(Sci-hub)
Abstract：
In the era of highly active antiretroviral therapy (HAART), disseminated Kaposi sarcoma (KS) has become much rarer in the USA. We report a case of a 34-year-old man with KS of the skin, oropharynx, lung and rectum. Within the same lung nodule, we discovered significant burden of colesional Cryptococcus neoformans, in the context of a positive asymptomatic cryptococcal antigenemia, which was a previously unreported occurrence. The gold standard of treatment for KS continues to be HAART. The role of chemotherapy is still controversial. In addition, a cryptococcal antigen screen-and-treat approach with fluconazole is still not routinely recommended in the USA to prevent serious meningeal disease despite recent studies showing efficacy and applicability. We discuss both issues here and the outcome of our patient. We also present the patient\'s own unique perspective in dealing with the ramifications of these diagnoses.
摘要：
在高活性抗逆转录病毒治疗（HAART）的时代，播散的卡波西肉瘤（KS）在美国已经变得更加罕见。我们报告了一个34岁的男性皮肤KS，口咽,肺和直肠。在同一个肺结节内，我们发现了巨大的新生隐球菌负担，在无症状隐球菌抗原血症阳性的情况下，这是以前未报告的事件。KS治疗的黄金标准仍然是HAART。化疗的作用仍有争议。此外,尽管最近的研究显示了疗效和适用性,但在美国仍不常规推荐使用氟康唑进行隐球菌抗原筛选和治疗以预防严重的脑膜疾病.我们在这里讨论这两个问题以及患者的结果。我们还提出了患者在处理这些诊断的后果方面的独特观点。
