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Abstract：
OBJECTIVE: Menopausal transition has been associated with an increased risk of cardiovascular disease (CVD), mainly attributed to atherogenic dyslipidaemia, central obesity and insulin resistance. Whether arterial hypertension (AH) also contributes to menopause-associated CVD is currently unknown. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the association between early menopause (EM) and AH risk.
METHODS: A comprehensive search was conducted in PubMed, CENTRAL and Scopus databases, up to January 20th, 2020. Data were expressed as odds ratio (OR) with 95 % confidence intervals (CI). The I2 index was employed for heterogeneity.
RESULTS: Ten studies were included in the quantitative analysis (273,994 postmenopausal women, 76853 cases with AH). Women with EM (age at menopause <45 years) were at higher AH risk compared with those of normal age at menopause (>45 years) (OR 1.10, 95 % CI 1.01-1.19, p = 0.03; I2 79 %). The direction or the magnitude of this association remained significant when the analysis was restricted to studies including groups matched for potential confounders, such as age, BMI, smoking or the use of menopausal hormone therapy or oral contraceptives.
CONCLUSIONS: Women with EM have an increased risk for AH compared with those of normal age at menopause.
METHODS: A comprehensive search was conducted in PubMed, CENTRAL and Scopus databases, up to January 20th, 2020. Data were expressed as odds ratio (OR) with 95 % confidence intervals (CI). The I2 index was employed for heterogeneity.
RESULTS: Ten studies were included in the quantitative analysis (273,994 postmenopausal women, 76853 cases with AH). Women with EM (age at menopause <45 years) were at higher AH risk compared with those of normal age at menopause (>45 years) (OR 1.10, 95 % CI 1.01-1.19, p = 0.03; I2 79 %). The direction or the magnitude of this association remained significant when the analysis was restricted to studies including groups matched for potential confounders, such as age, BMI, smoking or the use of menopausal hormone therapy or oral contraceptives.
CONCLUSIONS: Women with EM have an increased risk for AH compared with those of normal age at menopause.
摘要：
目的：更年期过渡与心血管疾病（CVD）的风险增加有关，主要归因于动脉粥样硬化的血脂异常，中心性肥胖和胰岛素抵抗。目前尚不清楚动脉高血压（AH）是否也与更年期相关的CVD有关。这项研究的目的是系统地调查和荟萃分析有关早期绝经（EM）与AH风险之间关联的最佳可用证据。
方法：在PubMed中进行了全面搜索，CENTRAL和Scopus数据库，直到1月20日,2020年。数据表示为比值比（OR），95%置信区间（CI）。I2指数用于异质性。
结果：10项研究纳入定量分析（273,994名绝经后妇女，76853例与AH）。与正常年龄（>45岁）的绝经女性相比，EM（绝经年龄<45岁）的AH风险更高（OR1.10，95％CI1.01-1.19，p=0.03；I279％）。当分析仅限于包括潜在混杂因素匹配组的研究时，这种关联的方向或大小仍然很重要。比如年龄,BMI,吸烟或使用更年期激素治疗或口服避孕药。
结论：与正常年龄的女性相比，绝经后女性患AH的风险增加。
方法：在PubMed中进行了全面搜索，CENTRAL和Scopus数据库，直到1月20日,2020年。数据表示为比值比（OR），95%置信区间（CI）。I2指数用于异质性。
结果：10项研究纳入定量分析（273,994名绝经后妇女，76853例与AH）。与正常年龄（>45岁）的绝经女性相比，EM（绝经年龄<45岁）的AH风险更高（OR1.10，95％CI1.01-1.19，p=0.03；I279％）。当分析仅限于包括潜在混杂因素匹配组的研究时，这种关联的方向或大小仍然很重要。比如年龄,BMI,吸烟或使用更年期激素治疗或口服避孕药。
结论：与正常年龄的女性相比，绝经后女性患AH的风险增加。
