METHODS: A comprehensive search was conducted in PubMed, CENTRAL and Scopus databases, up to January 20th, 2020. Data were expressed as odds ratio (OR) with 95 % confidence intervals (CI). The I2 index was employed for heterogeneity.
RESULTS: Ten studies were included in the quantitative analysis (273,994 postmenopausal women, 76853 cases with AH). Women with EM (age at menopause <45 years) were at higher AH risk compared with those of normal age at menopause (>45 years) (OR 1.10, 95 % CI 1.01-1.19, p = 0.03; I2 79 %). The direction or the magnitude of this association remained significant when the analysis was restricted to studies including groups matched for potential confounders, such as age, BMI, smoking or the use of menopausal hormone therapy or oral contraceptives.
CONCLUSIONS: Women with EM have an increased risk for AH compared with those of normal age at menopause.
方法:在PubMed中进行了全面搜索,CENTRAL和Scopus数据库,直到1月20日,2020年。数据表示为比值比(OR),95%置信区间(CI)。I2指数用于异质性。
结果:10项研究纳入定量分析(273,994名绝经后妇女,76853例与AH)。与正常年龄(>45岁)的绝经女性相比,EM(绝经年龄<45岁)的AH风险更高(OR1.10,95%CI1.01-1.19,p=0.03;I279%)。当分析仅限于包括潜在混杂因素匹配组的研究时,这种关联的方向或大小仍然很重要。比如年龄,BMI,吸烟或使用更年期激素治疗或口服避孕药。
结论:与正常年龄的女性相比,绝经后女性患AH的风险增加。