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Abstract：
The biofilm formation by oral bacteria on the implant surface is one of the most remarkable factors of peri-implant infections, which may eventually lead to bone resorption and loss of the dental implant. Therefore, the elimination of biofilm is an essential step for the successful therapy of implant-related infections. In this work we created a basic in vitro model to evaluate the antibacterial effect of three widely used antiseptics.Commercially pure (CP4) titanium sample discs with sand blasted, acid etched, and polished surface were used. The discs were incubated with mono-cultures of Streptococcus mitis and Streptococcus salivarius. The adhered bacterial biofilms were treated with different antiseptics: chlorhexidine-digluconate (CHX), povidone-iodine (PI), and chlorine dioxide (CD) for 5 min and the control discs with ultrapure water. The antibacterial effect of the antiseptics was tested by colorimetric assay.According to the results, the PI and the CD were statistically the most effective in the elimination of the two test bacteria on both titanium surfaces after 5 min treatment time. The CD showed significant effect only against S. salivarius.Based on our results we conclude that PI and CD may be promising antibacterial agents to disinfecting the peri-implant site in the dental practice.
摘要：
口腔细菌在种植体表面形成生物膜是种植体周围感染的最显著因素之一,这最终可能导致骨吸收和牙种植体的损失。因此,生物膜的消除是成功治疗植入物相关感染的重要步骤.在这项工作中，我们创建了一个基本的体外模型来评估三种广泛使用的防腐剂的抗菌作用。商业纯(CP4)钛样品盘，喷砂处理，酸蚀刻，和抛光表面使用。将圆盘与链球菌和唾液链球菌的单一培养物一起孵育。用不同的防腐剂处理粘附的细菌生物膜：氯己定-二葡萄糖酸盐（CHX），聚维酮碘（PI），和二氧化氯（CD）5分钟，用超纯水控制光盘。通过比色法测试抗菌剂的抗菌作用。根据结果,在5分钟处理时间后，PI和CD在消除两个钛表面上的两种测试细菌方面在统计学上最有效。CD仅对唾液链球菌显示出显著的效果。根据我们的结果，我们得出结论，PI和CD可能是在牙科实践中对种植体周围部位进行消毒的有前途的抗菌剂。
