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Abstract：
To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y-maze sociability testing. This unique \"sociophobia\" acquisition could be documented in independent cohorts. We therefore employed infrared thermography as a non-invasive method of stress-monitoring during SocioBox testing (presentation of five other mice) versus empty box. A higher Centralization Index (body/tail temperature) in the SocioBox correlated negatively with social recognition memory and, after 4 weeks, with social preference in the Y-maze. Assuming that social stimuli might be associated with characteristic thermo-responses, we exposed healthy men (N = 103) with a comparably high intelligence level to a standardized test session including two cognitive tests with or without social component (face versus pattern recognition). In some analogy to the Centralization Index (within-subject measure) used in mice, the Reference Index (ratio nose/malar cheek temperature) was introduced to determine the autonomic facial response/flushing during social recognition testing. Whereas cognitive performance and salivary cortisol were comparable across human subjects and tests, the Face Recognition Test was associated with a characteristic Reference Index profile. Infrared thermography may have potential for discriminating disturbed social behaviors.
摘要：
为了评估小鼠的复杂社会识别，我们以前开发了SocioBox范式。出乎意料的是,在SocioBox表演4周后，小鼠在Y迷宫社交能力测试中表现出强烈的社交回避。这种独特的“社会恐惧症”获得可以记录在独立的队列中。因此，我们在SocioBox测试（其他五只小鼠的展示）与空盒期间采用红外热成像作为压力监测的非侵入性方法。SocioBox中较高的集中指数(身体/尾巴温度)与社会识别记忆呈负相关，4周后,在Y迷宫中具有社会偏好。假设社会刺激可能与特征性的热反应有关，我们对智力水平相对较高的健康男性(N=103)进行标准化测试,包括两项有或没有社会成分的认知测试(面部与模式识别).类似于小鼠中使用的集中化指数(受试者内部测量)，在社会识别测试过程中，引入了参考指数（鼻子/唇颊温度比）来确定自主性面部反应/潮红。尽管认知表现和唾液皮质醇在人类受试者和测试中具有可比性，人脸识别测试与特征性参考指数曲线相关联。红外热成像可能具有区分受干扰的社会行为的潜力。
