%0 Journal Article
%T Vascular response to social cognitive performance measured by infrared thermography: A translational study from mouse to man.
%A Seidel J
%A Bockhop F
%A Mitkovski M
%A Martin S
%A Ronnenberg A
%A Krueger-Burg D
%A Schneider K
%A Röhse H
%A Wüstefeld L
%A Cosi F
%A Bröking K
%A Schacht A
%A Ehrenreich H
%J FASEB Bioadv
%V 2
%N 1
%D Jan 2020
%M 32123854
暂无%R 10.1096/fba.2019-00085
%X To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y-maze sociability testing. This unique "sociophobia" acquisition could be documented in independent cohorts. We therefore employed infrared thermography as a non-invasive method of stress-monitoring during SocioBox testing (presentation of five other mice) versus empty box. A higher Centralization Index (body/tail temperature) in the SocioBox correlated negatively with social recognition memory and, after 4 weeks, with social preference in the Y-maze. Assuming that social stimuli might be associated with characteristic thermo-responses, we exposed healthy men (N = 103) with a comparably high intelligence level to a standardized test session including two cognitive tests with or without social component (face versus pattern recognition). In some analogy to the Centralization Index (within-subject measure) used in mice, the Reference Index (ratio nose/malar cheek temperature) was introduced to determine the autonomic facial response/flushing during social recognition testing. Whereas cognitive performance and salivary cortisol were comparable across human subjects and tests, the Face Recognition Test was associated with a characteristic Reference Index profile. Infrared thermography may have potential for discriminating disturbed social behaviors.