关键词: DeNovo Particulated juvenile cartilage allograft transplantation cartilage repair juvenile cartilage osteochondral lesion talus

Mesh : Adolescent Allografts / transplantation Ankle / pathology surgery Cartilage, Articular / transplantation Humans Knee Joint / pathology surgery Talus / pathology surgery Transplantation, Homologous

来  源:   DOI:10.1080/17434440.2020.1733973   PDF(Sci-hub)

Abstract:
Introduction: Osteochondral lesions have been challenging to treat due to the limited regenerative capacity of native hyaline cartilage. Although surgical options are available, a newer technique, Particulated Juvenile Cartilage Allograft Transplantation (PJCAT) has shown promise for lesions of the knee and ankle. Short-term studies have been encouraging of its use, but there is still limited evidence of its long-term durability.Areas covered: This review will summarize the surgical options currently available for osteochondral lesions, outline the indications and contraindications of PJCAT, present the basic science and clinical evidence of the procedure, and describe the surgical approaches of this technique.Expert opinion: PJCAT is a promising method to treat osteochondral lesions. However, continued research is needed to document the efficacy of this technique and potential superiority over other techniques. Benefits include ease of application, potential for arthroscopic or minimally invasive delivery, no need for perpendicular access, no donor site morbidity, and delivery of viable chondrocytes in hyaline cartilage.
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