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Abstract：
Room temperature ionic liquids (ILs) are well established stationary phases (SPs) for gas chromatography (GC) in several fields of applications because of their unique and tunable selectivity, low vapor pressure and volatility, high thermal stability (over 300 °C), and good chromatographic properties. This study is focused on an IL based on a phosphonium derivative (trihexyl(tetradecyl)phosphonium chloride, [P66614+] [Cl-]), previously shown to be suitable as a gas chromatographic SP because of its unique selectivity. In particular, it aims to establish the operative conditions to apply [P66614+][Cl-] to routine analysis of samples containing medium to high volatility analytes with different polarity, organic functional groups and chemical structure. In the first part, the study critically evaluates long term [P66614+][Cl-] column stability and maximum allowable operating temperatures (MAOT). The relatively low MAOT (210 °C) requires the adoption of a dedicated approach for analytes eluting above this temperature based on a suitable combination of efficiency and selectivity, and column characteristics (length, inner diameter and film thickness) and operative conditions. The performance of [P66614+][Cl-] as a GC SP have been validated through the Grob test, a model mixture of 41 compounds of different polarity, structure, and with different organic functional groups in the flavor and fragrance field, a standard mixture of 37 fatty acid methyl esters, some essential oils containing pairs or groups of compounds of different volatility critical to separate in particular peppermint, thyme, oregano, sandalwood and frankincense. The above approach has produced highly satisfactory separations with all of the samples investigated.
摘要：
室温离子液体（ILs）由于其独特和可调的选择性，已在多个应用领域中用于气相色谱（GC）的固定相（SP）。低蒸气压和挥发性，高热稳定性（超过300°C），和良好的色谱性能。本研究的重点是基于磷衍生物（氯化三己基（十四烷基）磷，[P66614+][Cl-]),由于其独特的选择性，先前被证明适合用作气相色谱SP。特别是,它旨在建立将[P66614+][Cl-]应用于含有不同极性的中高挥发性分析物的样品的常规分析的操作条件，有机官能团和化学结构。在第一部分,该研究严格评估长期[P66614+][Cl-]色谱柱稳定性和最大允许操作温度（MAOT）。相对较低的MAOT（210°C）需要采用基于效率和选择性的合适组合的专用方法来洗脱高于该温度的分析物。和柱特征(长度，内径和薄膜厚度)和操作条件。[P66614+][Cl-]作为GCSP的性能已通过Grob测试进行了验证，41种不同极性化合物的模型混合物，结构,并具有不同的有机官能团，37种脂肪酸甲酯的标准混合物，一些精油含有不同挥发性的化合物对或组，对分离特别是薄荷至关重要，百里香,牛至,檀香和乳香.上述方法对所研究的所有样品都产生了非常令人满意的分离。
