关键词： Aspidopterys obcordata Malpighiaceae anti-inflammatory activity cytotoxic activity norditerpeniod

Mesh ： Animals Cell Line, Tumor Diterpenes / chemistry pharmacology Humans Magnetic Resonance Spectroscopy Malpighiaceae / chemistry Mice Models, Molecular Molecular Structure Nitric Oxide / metabolism Plant Extracts / chemistry pharmacology RAW 264.7 Cells

来  源：   DOI：10.3390/molecules25030529   PDF(Sci-hub)   PDF(Pubmed)

Abstract：
Four new diterpenoids, named aspidoptoids A-D (1-4), together with two known analogues (5-6) were isolated from Aspidopterys obcordata vine. Aspidoptoids A-B (1-2) are the first examples of phenylethylene-bearing 20-nor-diterpenoids of which aspidoptoid B (2) possesses a rare 3,10-oxybridge. Their structures and absolute configuration were determined by extensive spectroscopic analyses (IR, HRESIMS, 1D and 2D NMR) and electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their cytotoxic activities and inhibitory effects on the nitric oxide (NO) production.
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