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Abstract：
A consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to the science and policy of LCS: (1) weight management and glucose control; (2) consumption, safety and perception; (3) nutrition policy. The aims were to identify the reliable facts on LCS, suggest research gaps and propose future actions. The panel agreed that the safety of LCS is demonstrated by a substantial body of evidence reviewed by regulatory experts and current levels of consumption, even for high users, are within agreed safety margins. However, better risk communication is needed. More emphasis is required on the role of LCS in helping individuals reduce their sugar and energy intake, which is a public health priority. Based on reviews of clinical evidence to date, the panel concluded that LCS can be beneficial for weight management when they are used to replace sugar in products consumed in the diet (without energy substitution). The available evidence suggests no grounds for concerns about adverse effects of LCS on sweet preference, appetite or glucose control; indeed, LCS may improve diabetic control and dietary compliance. Regarding effects on the human gut microbiota, data are limited and do not provide adequate evidence that LCS affect gut health at doses relevant to human use. The panel identified research priorities, including collation of the totality of evidence on LCS and body weight control, monitoring and modelling of LCS intakes, impacts on sugar reduction and diet quality and developing effective communication strategies to foster informed choice. There is also a need to reconcile policy discrepancies between organisations and reduce regulatory hurdles that impede low-energy product development and reformulation.
摘要：
2018年11月举行了关于低热量甜味剂（LCS）的共识研讨会，十七名专家（小组讨论）讨论了确定为LCS科学和政策关键的三个主题：（1）体重管理和葡萄糖控制；（2）消费，安全和感知；(3)营养政策。目的是确定LCS的可靠事实，建议研究差距，并提出未来的行动。小组同意，由监管专家审查的大量证据和当前的消费水平证明了LCS的安全性，即使是高用户，在商定的安全裕度内。然而,需要更好的风险沟通。需要更多地强调LCS在帮助个人减少糖和能量摄入方面的作用，这是公共卫生的优先事项。根据迄今为止的临床证据，小组得出结论,当LCS用于替代饮食中消耗的产品中的糖(不含能量替代)时,LCS可有益于体重管理.现有证据表明，没有理由担心LCS对甜味偏好的不利影响，食欲或血糖控制；事实上，LCS可以改善糖尿病控制和饮食依从性。关于对人体肠道微生物群的影响，数据有限,没有提供足够的证据证明LCS在与人类使用相关的剂量下影响肠道健康.小组确定了研究重点，包括整理LCS和体重控制的全部证据，LCS摄入量的监测和建模，对降糖和饮食质量的影响，并制定有效的沟通策略以促进知情选择。还需要调和组织之间的政策差异，并减少阻碍低能耗产品开发和重新配方的监管障碍。
