PDF(Sci-hub)
Abstract：
BACKGROUND: Patients with penile schwannoma are rare and usually with variant presentations. No evidence-based clinical guideline exists for diagnosis or treatment. To put schwannoma into differential diagnoses of benign soft tissue lesions in the penis is important.
OBJECTIVE: To analyze and categorize clinical, histopathological, and radiological presentations and apply possible explanation on several fields of penile schwannoma.
METHODS: We collected the English literature through the PubMed database of the National Library of Medicine up to October 2019. A newly diagnosed case in Chang Gung Memorial Hospital, Taiwan, was also included. This study categorized lesion locations into the penile body or shaft, glans, or penile root, dorsal or ventral.
METHODS: The main outcome measure was to demonstrate clinical, pathological, ultrasonography, and MRI manifestations of penile schwannoma and perform immunohistochemistry staining that has not been performed among penile schwannomas.
RESULTS: We collected 40 cases. Data were arranged in tables. Clear descriptions were added on several fields of penile schwannoma in detail in Discussion.
CONCLUSIONS: Penile schwannomas are mostly located at the penile shaft and dorsum of the penis. Dyspareunia is the most reported complaint for sexual dysfunction. This study is the first study in the world to document the expressions of calretinin, SOX10, glial fibrillary acid protein, D2-40 (podoplanin), and cytokeratin AE1/AE3 in penile schwannoma and claims magnetic resonance imaging and pathologic presentations of penile schwannomas are synonymous with schwannomas from head to toe. The current patient may be the first to present with penile schwannoma with schwannomatosis. Huang LC, Wang HZ, Chu YC, et al. Clinicopathological Presentation and Management of Penile Schwannoma. Sex Med Rev 2020;8:615-621.
OBJECTIVE: To analyze and categorize clinical, histopathological, and radiological presentations and apply possible explanation on several fields of penile schwannoma.
METHODS: We collected the English literature through the PubMed database of the National Library of Medicine up to October 2019. A newly diagnosed case in Chang Gung Memorial Hospital, Taiwan, was also included. This study categorized lesion locations into the penile body or shaft, glans, or penile root, dorsal or ventral.
METHODS: The main outcome measure was to demonstrate clinical, pathological, ultrasonography, and MRI manifestations of penile schwannoma and perform immunohistochemistry staining that has not been performed among penile schwannomas.
RESULTS: We collected 40 cases. Data were arranged in tables. Clear descriptions were added on several fields of penile schwannoma in detail in Discussion.
CONCLUSIONS: Penile schwannomas are mostly located at the penile shaft and dorsum of the penis. Dyspareunia is the most reported complaint for sexual dysfunction. This study is the first study in the world to document the expressions of calretinin, SOX10, glial fibrillary acid protein, D2-40 (podoplanin), and cytokeratin AE1/AE3 in penile schwannoma and claims magnetic resonance imaging and pathologic presentations of penile schwannomas are synonymous with schwannomas from head to toe. The current patient may be the first to present with penile schwannoma with schwannomatosis. Huang LC, Wang HZ, Chu YC, et al. Clinicopathological Presentation and Management of Penile Schwannoma. Sex Med Rev 2020;8:615-621.
摘要：
背景：阴茎神经鞘瘤患者很少见，通常有变异表现。不存在用于诊断或治疗的循证临床指南。将神经鞘瘤纳入阴茎良性软组织病变的鉴别诊断中很重要。
目的：对临床、组织病理学,和放射学表现，并在阴茎神经鞘瘤的几个领域应用可能的解释。
方法：我们通过国家医学图书馆的PubMed数据库收集了截至2019年10月的英文文献。长庚纪念医院新诊断病例,台湾,也包括在内。这项研究将病变部位分类为阴茎体或阴茎轴，龟头,或阴茎根，背侧或腹侧。
方法：主要结果指标是证明临床，病态,超声检查,和阴茎神经鞘瘤的MRI表现，并进行了阴茎神经鞘瘤中未进行的免疫组织化学染色。
结果：我们收集了40例病例。数据排列在表中。在讨论中，对阴茎神经鞘瘤的几个领域进行了明确的描述。
结论：阴茎神经鞘瘤主要位于阴茎干和阴茎背侧。性交困难是报道最多的性功能障碍。这项研究是世界上第一个记录钙的表达的研究，SOX10,胶质纤维酸蛋白,D2-40(podoplanin),和阴茎神经鞘瘤中的细胞角蛋白AE1/AE3，并声称磁共振成像和阴茎神经鞘瘤的病理表现与从头到脚的神经鞘瘤同义。当前患者可能是第一个出现阴茎神经鞘瘤伴神经鞘瘤病的患者。黄LC，王HZ,ChuYC,etal.阴茎神经鞘瘤的临床病理表现和治疗。性医学修订版2020；8：615-621。
目的：对临床、组织病理学,和放射学表现，并在阴茎神经鞘瘤的几个领域应用可能的解释。
方法：我们通过国家医学图书馆的PubMed数据库收集了截至2019年10月的英文文献。长庚纪念医院新诊断病例,台湾,也包括在内。这项研究将病变部位分类为阴茎体或阴茎轴，龟头,或阴茎根，背侧或腹侧。
方法：主要结果指标是证明临床，病态,超声检查,和阴茎神经鞘瘤的MRI表现，并进行了阴茎神经鞘瘤中未进行的免疫组织化学染色。
结果：我们收集了40例病例。数据排列在表中。在讨论中，对阴茎神经鞘瘤的几个领域进行了明确的描述。
结论：阴茎神经鞘瘤主要位于阴茎干和阴茎背侧。性交困难是报道最多的性功能障碍。这项研究是世界上第一个记录钙的表达的研究，SOX10,胶质纤维酸蛋白,D2-40(podoplanin),和阴茎神经鞘瘤中的细胞角蛋白AE1/AE3，并声称磁共振成像和阴茎神经鞘瘤的病理表现与从头到脚的神经鞘瘤同义。当前患者可能是第一个出现阴茎神经鞘瘤伴神经鞘瘤病的患者。黄LC，王HZ,ChuYC,etal.阴茎神经鞘瘤的临床病理表现和治疗。性医学修订版2020；8：615-621。
