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Abstract：
Unilateral auditory deprivation results in lateralization changes in the central auditory system, interfering with the integration of binaural information and thereby leading to a decrease in binaural auditory functions such as sound localization. Principal neurons of the lateral superior olive (LSO) are responsible for computing the interaural intensity differences that are critical for sound localization in the horizontal plane. To investigate changes caused by unilateral auditory deprivation, electrophysiological activity was recorded from LSO principal neurons in control rats and rats with unilateral cochlear ablation. At one week after unilateral cochlear ablation, the excitability of LSO principal neurons on the side ipsilateral to the ablation (the ablated side) was greater than that on the side contralateral to the ablation (the intact side); however, the input resistance increased on both sides. Furthermore, by analysing the miniature inhibitory postsynaptic currents and miniature excitatory postsynaptic currents, we found that unilateral auditory deprivation weakened the inhibitory driving force on the intact side, whereas it strengthened the excitatory driving force on the ablated side. In summary, asymmetric changes in the electrophysiological activity of LSO principal neurons were found on both sides at postnatal day 19, one week after unilateral cochlear ablation.
摘要：
单侧听觉剥夺导致中枢听觉系统的侧化变化，干扰双耳信息的整合，从而导致双耳听觉功能的下降，如声音定位。外侧上橄榄（LSO）的主要神经元负责计算耳间强度差，这对于声音在水平面中的定位至关重要。为了调查由单侧听觉剥夺引起的变化，记录对照大鼠和单侧耳蜗消融大鼠的LSO主要神经元的电生理活动。单侧耳蜗消融后一周，消融同侧(消融侧)的LSO主神经元兴奋性大于消融对侧(完整侧);两侧的输入电阻都增加了。此外，通过分析微型抑制性突触后电流和微型兴奋性突触后电流，我们发现单侧听觉剥夺削弱了完整侧的抑制驱动力，而它加强了烧蚀侧的兴奋性驱动力。总之,单侧耳蜗消融后一周，出生后第19天，两侧发现LSO主要神经元的电生理活动不对称变化。
