关键词: familial hypercholesterolemia lipoprotein apheresis oxidative stress

Mesh : Adolescent Adult Aged Asian People Blood Component Removal / methods Child Female Humans Hyperlipoproteinemia Type II / blood therapy Lipids / blood Male Middle Aged Oxidative Stress Treatment Outcome Young Adult

来  源:   DOI:10.1002/jcla.23161   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
OBJECTIVE: Familial hypercholesterolemia (FH) characterized by severe high blood cholesterol levels usually presents an imbalance of systemic oxidative stress (OS). Lipoprotein apheresis (LA), which is the most effective therapy to reduce cholesterol levels, remains unclear in altering OS and scarce in Chinese patient studies. Our study aims to assess the impact of LA on OS status in Chinese patients with FH.
METHODS: About 31 patients (22 males, age: 12-69 years) with FH and receiving LA treatment were consecutive enrolled. Free oxygen radicals test (FORT) and free oxygen radicals defense (FORD) values were determined using the free oxygen radical monitor and kit immediately before and after LA, while blood samples were collected to measure plasma lipid levels and hs-CRP by conventional methods. Data were analyzed by paired t test or rank sum test and Spearman-rho correlation analysis.
RESULTS: Besides plasma lipid levels, the OS status showed that FORTs were significantly decreased and FORD values significantly enhanced immediately after LA treatment compared with before (both P < .01). In addition, the correlation analysis showed that the removal rates (△%) of TC were positively related to the increased rates (△%) of FORD value (ρ = 0.513, P = .003); LDL-C to FORD (ρ = 0.39, P = .03); Lp(a) to FORD (ρ = 0.473, P = .007); and non-HDL-C to FORD (ρ = 0.46, P = .009). However, no significant difference in hsCRP was found.
CONCLUSIONS: The present study indicated, besides effectively lowering plasma lipid levels, LA could significantly improve OS status in Chinese patients with FH.
摘要:
目的:以严重高血胆固醇水平为特征的家族性高胆固醇血症(FH)通常表现为全身氧化应激(OS)失衡。脂蛋白单采术(LA),这是降低胆固醇水平最有效的疗法,在改变OS方面仍不清楚,在中国患者研究中很少。我们的研究旨在评估LA对中国FH患者OS状态的影响。
方法:约31例患者(22例男性,年龄:12-69岁)患有FH并接受LA治疗的患者连续入选。在LA之前和之后立即使用游离氧自由基监测器和试剂盒确定游离氧自由基测试(FORT)和游离氧自由基防御(FORD)值,同时收集血液样本以通过常规方法测量血浆脂质水平和hs-CRP。数据采用配对t检验或秩和检验和Spearman-rho相关分析。
结果:除了血浆脂质水平,OS状态显示,与治疗前相比,LA治疗后即刻FORT值显著降低,FORD值显著提高(均P<.01).此外,相关分析表明,TC的去除率(△%)与FORD值(ρ=0.513,P=.003)的增加率(△%)正相关;LDL-C对FORD(ρ=0.39,P=.03);Lp(a)对FORD(ρ=0.473,P=.007);非HDL-C对FORD(ρ=0.46,P=.009)。然而,hsCRP无显著差异。
结论:本研究表明,除了有效降低血浆脂质水平,LA可以显着改善中国FH患者的OS状态。
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