PDF(Pubmed)
Abstract：
Sleep-disordered breathing (SDB) is a highly prevalent condition affecting 2% to 4% of children. However, the prevalence and characteristics of SDB in children younger than 2 years and the effect of prematurity as a risk factor remains unclear.
Children younger than 24 months referred for PSG at two medical centers between the years 2014 to 2018 were included in this retrospective analysis. We excluded children with genetic syndromes. Polysomnography (PSG) was performed and scored according to American Academy of Sleep Medicine guidelines.
Ninety-eight children were included (age 14.1 ± 6.4 [2-23] months), with 31 born prematurely (PRETERM; 24 to 34 weeks gestational age). PRETERM had increased odds of SDB (age and sex adjusted), using a cutoff of AHI ≥ 5 events/h with an odds ratio of 4.3 (95% confidence interval 1.5-12.9). Gestational age was the only significant predictor for SDB in this cohort, every additional week of gestation reducing the odds of SDB by 12.5%. PRETERM SDB was also characterized by more severe nocturnal hypoxemia, increased frequency of central apnea, and altered sleep architecture.
Current findings underscore the importance of prematurity antecedents as a risk factor for SDB in young symptomatic children younger than 2 years referred for a PSG. Future studies focused on improved estimates of the prevalence of SDB among nonreferral young children appear warranted.
Children younger than 24 months referred for PSG at two medical centers between the years 2014 to 2018 were included in this retrospective analysis. We excluded children with genetic syndromes. Polysomnography (PSG) was performed and scored according to American Academy of Sleep Medicine guidelines.
Ninety-eight children were included (age 14.1 ± 6.4 [2-23] months), with 31 born prematurely (PRETERM; 24 to 34 weeks gestational age). PRETERM had increased odds of SDB (age and sex adjusted), using a cutoff of AHI ≥ 5 events/h with an odds ratio of 4.3 (95% confidence interval 1.5-12.9). Gestational age was the only significant predictor for SDB in this cohort, every additional week of gestation reducing the odds of SDB by 12.5%. PRETERM SDB was also characterized by more severe nocturnal hypoxemia, increased frequency of central apnea, and altered sleep architecture.
Current findings underscore the importance of prematurity antecedents as a risk factor for SDB in young symptomatic children younger than 2 years referred for a PSG. Future studies focused on improved estimates of the prevalence of SDB among nonreferral young children appear warranted.
摘要：
睡眠呼吸紊乱（SDB）是一种非常普遍的疾病，影响2％至4％的儿童。然而,SDB在2岁以下儿童中的患病率和特征以及早产作为危险因素的影响尚不清楚.
这项回顾性分析包括2014年至2018年间在两个医疗中心转诊的24个月以下的PSG儿童。我们排除了患有遗传综合征的儿童。根据美国睡眠医学学会指南进行多导睡眠图(PSG)并评分。
98名儿童（年龄14.1±6.4[2-23]个月）早产31例（PRETERM；胎龄24至34周）。PRETERM增加了SDB（年龄和性别调整）的几率，使用AHI≥5个事件/h的截止值,比值比为4.3(95%置信区间1.5-12.9).妊娠年龄是该队列中SDB的唯一重要预测指标，妊娠每增加一周，SDB的几率就会降低12.5%。PRETERMSDB的特征还在于更严重的夜间低氧血症，中枢呼吸暂停的频率增加，和改变睡眠结构。
目前的研究结果强调了早产前因素作为PSG转诊的2岁以下有症状儿童中SDB的危险因素的重要性。未来的研究集中在改善非转诊幼儿中SDB患病率的估计似乎是有必要的。
这项回顾性分析包括2014年至2018年间在两个医疗中心转诊的24个月以下的PSG儿童。我们排除了患有遗传综合征的儿童。根据美国睡眠医学学会指南进行多导睡眠图(PSG)并评分。
98名儿童（年龄14.1±6.4[2-23]个月）早产31例（PRETERM；胎龄24至34周）。PRETERM增加了SDB（年龄和性别调整）的几率，使用AHI≥5个事件/h的截止值,比值比为4.3(95%置信区间1.5-12.9).妊娠年龄是该队列中SDB的唯一重要预测指标，妊娠每增加一周，SDB的几率就会降低12.5%。PRETERMSDB的特征还在于更严重的夜间低氧血症，中枢呼吸暂停的频率增加，和改变睡眠结构。
目前的研究结果强调了早产前因素作为PSG转诊的2岁以下有症状儿童中SDB的危险因素的重要性。未来的研究集中在改善非转诊幼儿中SDB患病率的估计似乎是有必要的。
