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Abstract：
Computer-assisted combined indocyanine green (ICG) molecular fluorescence imaging technology can be used for preoperative planning and intraoperative detection from three-dimensional (3D) morphological anatomy and level of cellular function to guide the anatomical, functional and radical hepatectomy of liver tumor. This technology has received wide acceptance and has shown important diagnostic and therapeutic value. This guideline is intended to standardize the application of computer-assisted combined ICG molecular fluorescence imaging for accurate diagnosis and treatment of liver tumors in the following aspects: (1) the workflow of 3D visualization technology; (2) the mechanism and application flow of ICG molecular fluorescence imaging; (3) clinical application of 3D visualization technology and virtual reality technology; and (4) clinical application of ICG molecular fluorescence imaging. ICG molecular fluorescence imaging can help to define tumor boundary, determine hepatic segment and hepatic lobectomy tangent at the molecular and cellular level, and detect small lesions or metastases. According to the fluorescence signal characteristics of liver tumors and combined with rapid frozen pathological examination during operation, the differentiation degree of liver space-occupying lesions (such as primary liver cancer) can be preliminarily determined, and residual tumors and biliary leakage on the hepatic section can be detected after hepatectomy. Computer-assisted ICG molecular fluorescence imaging in the diagnosis and surgical navigation of liver tumors provides a new approach to digital diagnosis and treatment of liver tumors. With its development in clinical practice and the technological innovation, this technology will be further improved to allow more accurate diagnosis and treatment of liver tumors.
摘要：
计算机辅助联合吲哚菁绿(ICG)分子荧光成像技术可用于术前规划和术中检测从三维(3D)形态解剖和细胞功能水平指导解剖,肝肿瘤的功能性和根治性肝切除术。该技术已被广泛接受并显示出重要的诊断和治疗价值。本指南旨在规范计算机辅助联合ICG分子荧光成像在肝肿瘤精准诊断和治疗中的应用,主要体现在以下几个方面:(1)三维可视化技术的工作流程;(2)ICG分子荧光成像的机理和应用流程;(3)三维可视化技术和虚拟现实技术的临床应用;(4)ICG分子荧光成像的临床应用。ICG分子荧光成像可以帮助确定肿瘤边界，在分子和细胞水平上确定肝段和肝叶切除切线，并检测到小的病变或转移。根据肝脏肿瘤的荧光信号特点,结合术中快速冰冻病理检查,可初步确定肝脏占位性病变(如原发性肝癌)的分化程度,肝切除术后可以检测到肝切片上残留的肿瘤和胆漏。计算机辅助ICG分子荧光成像在肝肿瘤诊断和手术导航中的应用为肝肿瘤的数字化诊断和治疗提供了新的途径。随着其在临床实践中的发展和技术创新,这项技术将得到进一步改进，以便更准确地诊断和治疗肝脏肿瘤。
