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Abstract：
Symptoms of gastroparesis (Gp) can fluctuate at different times of the day. Our aims are (1) To characterize Gp symptom variability throughout the day and in relation to meals and (2) to compare the daily symptom variability in subtypes of Gp-diabetic gastroparesis (DGp) and idiopathic gastroparesis (IGp).
Patients with Gp filled Patient Assessment of Gastrointestinal Symptoms (PAGI-SYM) and completed a modified GCSI-DD seven times a day (GCSI-Throughout the Day [GCSI-TTD]; before and after meals, and before going to bed) over a 2-week period. KEY RESULTS: A total of 44 patients participated (86% females), including 29 (66%) with IGp, 13 (30%) with DGp, and 2 (4%) with postsurgical Gp. Using the GCSI-TTD, patients with Gp reported significant postprandial worsening of overall symptom severity, as well as severities of nausea, early satiety, stomach fullness, and abdominal pain. Patients also had progressive worsening of the overall symptom severity, early satiety, stomach fullness, and abdominal pain during the day; however, nausea severity did not differ during the day. Number of vomiting and retching episodes did not show significant variations postprandially or during the day. Patients with IGp had greater symptom severity throughout the day and greater postprandial increase in symptoms compared to patients with DGp. CONCLUSIONS AND INFERENCES: Patients with Gp experience postprandial worsening of overall symptom severity, as well as severities of nausea, early satiety, stomach fullness, and abdominal pain. These symptoms also progressively worsen during the day, except for the severity of nausea which persists throughout the day. Understanding the symptom variability in patients with Gp throughout the day and postprandially may be useful in treatment of patients with Gp.
Patients with Gp filled Patient Assessment of Gastrointestinal Symptoms (PAGI-SYM) and completed a modified GCSI-DD seven times a day (GCSI-Throughout the Day [GCSI-TTD]; before and after meals, and before going to bed) over a 2-week period. KEY RESULTS: A total of 44 patients participated (86% females), including 29 (66%) with IGp, 13 (30%) with DGp, and 2 (4%) with postsurgical Gp. Using the GCSI-TTD, patients with Gp reported significant postprandial worsening of overall symptom severity, as well as severities of nausea, early satiety, stomach fullness, and abdominal pain. Patients also had progressive worsening of the overall symptom severity, early satiety, stomach fullness, and abdominal pain during the day; however, nausea severity did not differ during the day. Number of vomiting and retching episodes did not show significant variations postprandially or during the day. Patients with IGp had greater symptom severity throughout the day and greater postprandial increase in symptoms compared to patients with DGp. CONCLUSIONS AND INFERENCES: Patients with Gp experience postprandial worsening of overall symptom severity, as well as severities of nausea, early satiety, stomach fullness, and abdominal pain. These symptoms also progressively worsen during the day, except for the severity of nausea which persists throughout the day. Understanding the symptom variability in patients with Gp throughout the day and postprandially may be useful in treatment of patients with Gp.
摘要：
胃轻瘫（Gp）的症状可以在一天的不同时间波动。我们的目标是（1）表征全天Gp症状的变异性以及与进餐的关系；（2）比较Gp-糖尿病性胃轻瘫（DGp）和特发性胃轻瘫（IGp）亚型的每日症状变异性。
患有Gp的患者填写了胃肠道症状的患者评估（PAGI-SYM），并每天七次完成改良的GCSI-DD（GCSI-全天[GCSI-TTD]；饭前和饭后，和睡觉前)超过2周的时间。主要结果：共有44名患者参加（86％为女性），包括29（66%）的IGp，13（30%）与DGp，术后Gp为2（4％）。使用GCSI-TTD，Gp患者报告总体症状严重程度显著餐后恶化，以及恶心的严重性，早期饱腹感,肚子丰满，和腹痛。患者的整体症状严重程度也逐渐恶化，早期饱腹感,肚子丰满，和腹部疼痛在白天;然而,白天恶心的严重程度没有差异.在餐后或白天，呕吐和干草发作的次数没有显着变化。与DGp患者相比，IGp患者全天症状严重程度更高，餐后症状增加更大。结论和推论：Gp患者餐后总体症状严重程度恶化，以及恶心的严重性，早期饱腹感,肚子丰满，和腹痛。这些症状在白天也逐渐恶化，除了恶心的严重程度持续一整天。了解Gp患者全天和餐后的症状变异性可能对治疗Gp患者有用。
患有Gp的患者填写了胃肠道症状的患者评估（PAGI-SYM），并每天七次完成改良的GCSI-DD（GCSI-全天[GCSI-TTD]；饭前和饭后，和睡觉前)超过2周的时间。主要结果：共有44名患者参加（86％为女性），包括29（66%）的IGp，13（30%）与DGp，术后Gp为2（4％）。使用GCSI-TTD，Gp患者报告总体症状严重程度显著餐后恶化，以及恶心的严重性，早期饱腹感,肚子丰满，和腹痛。患者的整体症状严重程度也逐渐恶化，早期饱腹感,肚子丰满，和腹部疼痛在白天;然而,白天恶心的严重程度没有差异.在餐后或白天，呕吐和干草发作的次数没有显着变化。与DGp患者相比，IGp患者全天症状严重程度更高，餐后症状增加更大。结论和推论：Gp患者餐后总体症状严重程度恶化，以及恶心的严重性，早期饱腹感,肚子丰满，和腹痛。这些症状在白天也逐渐恶化，除了恶心的严重程度持续一整天。了解Gp患者全天和餐后的症状变异性可能对治疗Gp患者有用。
