Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (Translated Version).

2016 年日本结肠直肠癌学会 （ JSCCR ） 遗传性结直肠癌临床实践指南 （ 翻译版 ） 。

• 发表时间: 2018
• 来源期刊: J Anus Rectum Colon
• DOI: 10.23922/jarc.2017-028
• PMID: 31773066
• 文章类型: Journal Article
• 作者列表: Ishida H,Yamaguchi T,Tanakaya K,Akagi K,Inoue Y,Kumamoto K,Shimodaira H,Sekine S,Tanaka T,Chino A,Tomita N,Nakajima T,Hasegawa H,Hinoi T,Hirasawa A,Miyakura Y,Murakami Y,Muro K,Ajioka Y,Hashiguchi Y,Ito Y,Saito Y,Hamaguchi T,Ishiguro M,Ishihara S,Kanemitsu Y,Kawano H,Kinugasa Y,Kokudo N,Murofushi K,Nakajima T,Oka S,Sakai Y,Tsuji A,Uehara K,Ueno H,Yamazaki K,Yoshida M,Yoshino T,Boku N,Fujimori T,Itabashi M,Koinuma N,Morita T,Nishimura G,Sakata Y,Shimada Y,Takahashi K,Tanaka S,Tsuruta O,Yamaguchi T,Sugihara K,Watanabe T,

关键词: Lynch syndrome; familial adenomatous polyposis; guideline; hereditary colorectal cancer

Abstract

Hereditary colorectal cancer accounts for less than 5% of all colorectal cancer cases. Some of the unique characteristics that are commonly encountered in cases of hereditary colorectal cancer include early age at onset, synchronous/metachronous occurrence of the cancer, and association with multiple cancers in other organs, necessitating different management from sporadic colorectal cancer. While the diagnosis of familial adenomatous polyposis might be easy because usually 100 or more adenomas that develop in the colonic mucosa are in this condition, Lynch syndrome, which is the most commonly associated disease with hereditary colorectal cancer, is often missed in daily medical practice because of its relatively poorly defined clinical characteristics. In addition, the disease concept and diagnostic criteria for Lynch syndrome, which was once called hereditary non-polyposis colorectal cancer, have changed over time with continual research, thereby possibly creating confusion in clinical practice. Under these circumstances, the JSCCR Guideline Committee has developed the \"JSCCR Guidelines 2016 for the Clinical Practice of Hereditary Colorectal Cancer (HCRC),\" to allow delivery of appropriate medical care in daily practice to patients with familial adenomatous polyposis, Lynch syndrome, or other related diseases. The JSCCR Guidelines 2016 for HCRC were prepared by consensus reached among members of the JSCCR Guideline Committee, based on a careful review of the evidence retrieved from literature searches, and considering the medical health insurance system and actual clinical practice settings in Japan. Herein, we present the English version of the JSCCR Guidelines 2016 for HCRC.

摘要

遗传性结直肠癌占所有结直肠癌病例的不到5%。遗传性结直肠癌病例中常见的一些独特特征包括发病年龄较早，癌症的同步/异时发生，与其他器官的多种癌症有关，需要与散发性结直肠癌不同的治疗方法。虽然家族性腺瘤性息肉病的诊断可能很容易，因为通常在结肠粘膜中发展的100个或更多的腺瘤处于这种状况，林奇综合征,这是遗传性结直肠癌最常见的相关疾病，在日常医疗实践中经常被遗漏，因为它的临床特征相对不明确。此外,Lynch综合征的疾病概念和诊断标准，曾经被称为遗传性非息肉病性结直肠癌，随着时间的推移，不断的研究发生了变化，从而可能在临床实践中造成混乱。在这种情况下,JSCCR指南委员会制定了“2016年JSCCR指南，用于遗传性结直肠癌（HCRC）的临床实践，“为了在日常实践中为家族性腺瘤性息肉病患者提供适当的医疗服务，林奇综合征,或其他相关疾病。《JSCCR指导原则2016》由JSCCR指导原则委员会成员达成共识，根据对文献检索中找到的证据的仔细审查，并考虑日本的医疗健康保险制度和实际临床实践设置。在这里，我们为HCRC提供2016年JSCCR指南的英文版。