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Abstract：
OBJECTIVE: To present current evidence on the etiology, risk factors, diagnosis, and management of early and late neonatal sepsis.
METHODS: Non-systematic review of the Medline (PubMed), Scopus, Web of Science, Cochrane, and Google Scholar databases regarding the following terms: neonatal sepsis, early neonatal sepsis, late neonatal sepsis, empirical antibiotic therapy, sepsis calculator, vancomycin, newborn, preterm newborn.
RESULTS: Neonatal sepsis is a frequent cause of neonatal morbidity and mortality. Its diagnosis is difficult. Continuous observation of the patient is critical to diagnostic suspicion. When neonatal sepsis is suspected, bacteriological tests should be collected. Vancomycin should not be routinely using in the empirical antibiotic regimen in late neonatal sepsis, and the main protective mechanisms against neonatal sepsis are handwashing and the use of breast milk.
CONCLUSIONS: Newborns constitute a group that is more vulnerable to sepsis. Knowledge of risk factors and etiological agents allows a better approach to the newborn with sepsis.
METHODS: Non-systematic review of the Medline (PubMed), Scopus, Web of Science, Cochrane, and Google Scholar databases regarding the following terms: neonatal sepsis, early neonatal sepsis, late neonatal sepsis, empirical antibiotic therapy, sepsis calculator, vancomycin, newborn, preterm newborn.
RESULTS: Neonatal sepsis is a frequent cause of neonatal morbidity and mortality. Its diagnosis is difficult. Continuous observation of the patient is critical to diagnostic suspicion. When neonatal sepsis is suspected, bacteriological tests should be collected. Vancomycin should not be routinely using in the empirical antibiotic regimen in late neonatal sepsis, and the main protective mechanisms against neonatal sepsis are handwashing and the use of breast milk.
CONCLUSIONS: Newborns constitute a group that is more vulnerable to sepsis. Knowledge of risk factors and etiological agents allows a better approach to the newborn with sepsis.
摘要：
目的：为了提供有关病因的最新证据，危险因素，诊断,早期和晚期新生儿败血症的管理。
方法：Medline（PubMed）的非系统评价，Scopus,WebofScience,科克伦,和谷歌学者数据库关于以下术语：新生儿败血症，早期新生儿败血症,晚期新生儿败血症，经验性抗生素治疗，脓毒症计算器,万古霉素,新生,早产新生儿。
结果：新生儿败血症是新生儿发病和死亡的常见原因。它的诊断是困难的。对患者的持续观察对于诊断怀疑至关重要。当怀疑新生儿败血症时，应收集细菌学测试。万古霉素不应在晚期新生儿败血症的经验性抗生素方案中常规使用，对新生儿败血症的主要保护机制是洗手和使用母乳。
结论：新生儿是一个更容易感染脓毒症的群体。对危险因素和病因的了解可以更好地治疗脓毒症新生儿。
方法：Medline（PubMed）的非系统评价，Scopus,WebofScience,科克伦,和谷歌学者数据库关于以下术语：新生儿败血症，早期新生儿败血症,晚期新生儿败血症，经验性抗生素治疗，脓毒症计算器,万古霉素,新生,早产新生儿。
结果：新生儿败血症是新生儿发病和死亡的常见原因。它的诊断是困难的。对患者的持续观察对于诊断怀疑至关重要。当怀疑新生儿败血症时，应收集细菌学测试。万古霉素不应在晚期新生儿败血症的经验性抗生素方案中常规使用，对新生儿败血症的主要保护机制是洗手和使用母乳。
结论：新生儿是一个更容易感染脓毒症的群体。对危险因素和病因的了解可以更好地治疗脓毒症新生儿。
