PDF(Sci-hub)
Abstract：
Emerging and emergent infectious diseases (EIDs) represent a significant and growing cause of morbidity and mortality with increased potential for pandemics due to globalization and international trade. Challenges remain to the approach toward vaccine development for EIDs. This Special Feature explores areas related to vaccine development and testing, including unique challenges posed in the developing world. Vaccines against multiple pathogens spanning a number of viral families are explored with respect to past activities through to future commercialization. Cost drivers balanced against clinical need are discussed and unique challenges posed by rare diseases are considered.
摘要：
新兴和新兴传染病（EID）是发病率和死亡率的重要且不断增长的原因，由于全球化和国际贸易，大流行的可能性增加。EID疫苗开发方法仍然面临挑战。本专题探讨了与疫苗开发和测试相关的领域，包括发展中国家面临的独特挑战。针对跨越多个病毒家族的多种病原体的疫苗从过去的活动到未来的商业化进行了探索。讨论了与临床需求相平衡的成本驱动因素，并考虑了罕见疾病带来的独特挑战。
