香草醛衍生物 VND3207 通过调节 p53 / NOXA 信号通路和恢复肠道微生物群的平衡来保护肠道免受辐射损伤。
关键词: Intestinal flora NOXA Radiation-induced intestinal injuries Reactive oxygen species (ROS) VND3207 p53
Mesh : Animals Antioxidants / pharmacology Benzaldehydes / chemistry pharmacology Cell Lineage / drug effects radiation effects Gastrointestinal Microbiome / genetics radiation effects Gene Expression Regulation / drug effects radiation effects Humans Intestines / drug effects Mice Oxidative Stress / drug effects Proto-Oncogene Proteins c-bcl-2 / genetics Radiation Exposure / adverse effects Radiation Injuries / genetics prevention & control Radiation Tolerance / genetics Receptors, G-Protein-Coupled / genetics Signal Transduction / radiation effects Stem Cells / drug effects Tumor Suppressor Protein p53 / genetics
来 源:
DOI:10.1016/j.freeradbiomed.2019.09.035
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