关键词: SALL4 SOX2 choriocarcinoma chromosome 12p embryonal carcinoma extragonadal germ cell tumors seminoma teratoma yolk sac tumor

Mesh : Biomarkers, Tumor / blood Humans Neoplasms, Germ Cell and Embryonal / epidemiology metabolism pathology therapy Prognosis

来  源:   DOI:10.1002/cam4.2195   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis.
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