%0 Journal Article
%T Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features.
%A Ronchi A
%A Cozzolino I
%A Montella M
%A Panarese I
%A Zito Marino F
%A Rossetti S
%A Chieffi P
%A Accardo M
%A Facchini G
%A Franco R
%J Cancer Med
%V 8
%N 16
%D 11 2019
%M 31568647
%F 4.711
%R 10.1002/cam4.2195
%X Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis.