PDF(Sci-hub)
Abstract：
The study of the human microbiome has led to an exceptional increase in the current understanding of the importance of microbiota for health throughout all stages of life. Human microbial colonization occurs in the skin, genitourinary system and, mainly, in the oral cavity and intestinal tract. In these locations, the human microbiota establishes a symbiotic relationship with the host and helps maintain the physiological homeostasis. Lifestyle, age, diet and use of antibiotics are the main regulators of the composition and functionality of human microbiota. Recent studies have indicated the reduction in microbial diversity as one of the contributors to the development of diseases. In addition to phylogenetic diversity studies, further metagenomic studies are needed at the functional level of the human microbiome to improve our understanding of its involvement in human health.
摘要：
对人类微生物组的研究导致了目前对微生物群在生命各个阶段对健康的重要性的理解的异常增加。人类微生物定植发生在皮肤上，泌尿生殖系统和,主要是,在口腔和肠道。在这些地方,人类微生物群与宿主建立共生关系，并有助于维持生理稳态。生活方式,年龄,饮食和抗生素的使用是人类微生物群组成和功能的主要调节剂。最近的研究表明，微生物多样性的减少是疾病发展的原因之一。除了系统发育多样性研究，需要在人类微生物组的功能层面进行进一步的宏基因组研究,以提高我们对其参与人类健康的认识.
