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Abstract：
The role and utility of intrinsically disordered regions (IDRs) is reviewed for two groups of sarcomeric proteins, such as members of tropomodulin/leiomodin (Tmod/Lmod) protein homology group and myosin binding protein C (MyBP-C). These two types of sarcomeric proteins represent very different but strongly interdependent functions, being responsible for maintaining structure and operation of the muscle sarcomere. The role of IDRs in the formation of complexes between thin filaments and Tmods/Lmods is discussed within the framework of current understanding of the thin filament length regulation. For MyBP-C, the function of IDRs is discussed in the context of MYBP-C-dependent sarcomere contraction and actomyosin activation.
摘要：
对两组肌节蛋白的内在无序区域（IDR）的作用和实用性进行了综述，例如原调节素/leiomoodin（Tmod/Lmod）蛋白同源组和肌球蛋白结合蛋白C（MyBP-C）的成员。这两种类型的肌节蛋白代表了非常不同但强烈相互依存的功能，负责维护肌肉肌节的结构和操作。在当前对细丝长度调节的理解框架内，讨论了IDR在细丝与Tmods/Lmods之间形成复合物中的作用。对于MyBP-C，在MYBP-C依赖性肌节收缩和肌动球蛋白激活的背景下讨论了IDR的功能。
