水飞蓟宾通过调节 CFLAR - JNK 途径改善非酒精性脂肪性肝炎小鼠肝脏脂质积累和氧化应激。
关键词: 2-NBDG, 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino)-2-deoxyglucose ALT, alanine aminotransferase AST, aspartate aminotransferase Acox, acyl-coenzyme A oxidase X Akt, serine–threonine protein kinase CAT, catalase CFLAR CFLAR, caspase 8 and Fas-associated protein with death domain-like apoptosis regulator CYP2E1, cytochrome P450 2E1 CYP4A, cytochrome P450 4A Cpt1α, carnitine palmitoyl transferase 1α Fabp5, fatty acid-binding proteins 5 GSH-Px, glutathione peroxidase Gpat, glycerol-3-phosphate acyltransferase HE, hematoxylin–eosin HO-1, heme oxygenase 1 IR, insulin resistance IRS1, insulin receptor substrate 1 JNK, c-Jun N-terminal kinase Lipid accumulation MAPK, mitogen-activated protein kinase MCD, methionine- and choline-deficient MCS, methionine- and choline-sufficient MDA, malondialdehyde MT, Masson–Trichrome Mttp, microsomal triglyceride transfer protein NAFLD, non-alcoholic fatty liver disease NASH NASH, nonalcoholic steatohepatitis NF-κB, nuclear factor κB NRF2, nuclear factor erythroid 2-related factor 2 OA, oleic acid ORO, oil red O Oxidation stress PA, palmitic acid PI3K, phosphatidylinositol 3-hydroxy kinase Pnpla3, phospholipase domain containing 3 Pparα, peroxisome proliferator activated receptor α SD, Sprague–Dawley Scd-1, stearoyl-coenzyme A desaturase-1 Silibinin Srebp-1c, sterol regulatory element binding protein-1C TC, total cholesterol TG, triglyceride pIRS1, phosphorylation of insulin receptor substrate 1 pJNK, phosphorylation of c-Jun N-terminal kinase
来 源:
DOI:10.1016/j.apsb.2019.02.006
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